Robust spatially resolved pressure measurements using MRI with novel buoyant advection-free preparations of stable microbubbles in polysaccharide gels

Morris, Robert, Bencsik, Martin, Nestle, Nikolaus, Galvosas, Petrik, Fairhurst, David, Vangala, Anil, Perrie, Yvonne and McHale, Glen (2008) Robust spatially resolved pressure measurements using MRI with novel buoyant advection-free preparations of stable microbubbles in polysaccharide gels. Journal of Magnetic Resonance, 193 (2). pp. 159-167. ISSN 1090-7807

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Official URL: http://dx.doi.org/10.1016/j.jmr.2008.04.025

Abstract

MRI of fluids containing lipid coated microbubbles has been shown to be an effective tool for measuring the local fluid pressure. However, the intrinsically buoyant nature of these microbubbles precludes lengthy measurements due to their vertical migration under gravity and pressure-induced coalescence. A novel preparation is presented which is shown to minimize both these effects for at least 25 min. By using a 2% polysaccharidegel base with a small concentration of glycerol and 1,2-distearoyl-sn-glycero-3-phosphocholine coated gas microbubbles, MR measurements are made for pressures between 0.95 and 1.44 bar. The signal drifts due to migration and amalgamation are shown to be minimized for such an experiment whilst yielding very high NMR sensitivities up to 38% signal change per bar.

Item Type: Article
Uncontrolled Keywords: gas filled lipid coated microbubbles, pressure, polysaccharide, MRI, diffusion, viscosity, contrast agent
Subjects: F300 Physics
Department: Faculties > Engineering and Environment > Physics and Electrical Engineering
Depositing User: Ay Okpokam
Date Deposited: 01 Feb 2012 10:44
Last Modified: 12 May 2017 00:20
URI: http://nrl.northumbria.ac.uk/id/eprint/5152

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