Development of a combined surface plasmon resonance/surface acoustic wave device for the characterization of biomolecules

Bender, Florian, Roach, Paul, Tsortos, Achilleas, Papadakis, George, Newton, Michael, McHale, Glen and Gizeli, Electra (2009) Development of a combined surface plasmon resonance/surface acoustic wave device for the characterization of biomolecules. Measurement Science and Technology, 20 (12). p. 124011. ISSN 0957-0233

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Official URL: http://dx.doi.org/10.1088/0957-0233/20/12/124011

Abstract

It is known that acoustic sensor devices, if operated in liquid phase, are sensitive not just to the mass of the analyte but also to various other parameters, such as size, shape, charge and elastic constants of the analyte as well as bound and viscously entrained water. This can be used to extract valuable information about a biomolecule, particularly if the acoustic device is combined with another sensor element which is sensitive to the mass or amount of analyte only. The latter is true in good approximation for various optical sensor techniques. This work reports on the development of a combined surface plasmon resonance/surface acoustic wave sensor system which is designed for the investigation of biomolecules such as proteins or DNA. Results for the deposition of neutravidin and DNA are reported.

Item Type: Article
Uncontrolled Keywords: SAW, SPR, biosensor, viscoelastic effects, biorecognition
Subjects: C700 Molecular Biology, Biophysics and Biochemistry
Department: Faculties > Engineering and Environment > Physics and Electrical Engineering
Depositing User: Ay Okpokam
Date Deposited: 01 Feb 2012 10:43
Last Modified: 11 May 2017 15:18
URI: http://nrl.northumbria.ac.uk/id/eprint/5161

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