Novel peptidase substrates

Biomerieux SA, Fabrega Olivier, James Arthur L., Orenga Sylvain, Perry, John D., Salwatura,Vindhya L., Stanforth, Stephen (2011) Novel peptidase substrates. WO2011012807 (A2), US 20120129203 A1.

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Abstract

The present invention relates to the use of a compound of the following formula (I) for detecting a peptidase activity and/or a variation in pH: according to which: Y1 is a peptide, H or an alkyl W1, W2, W3 and W4 are independently H, Br, Cl, F, I, alkyl, alkoxy, thiomethyl, perfluoroalkyl, nitro, cyano, carboxyl (including the esters or amides thereof) or any combination thereof n = 0, 1 or 2 X is NR, CZ5Z6, S or O, R being H, alkyl, aralkyl, aryl, alkanoic or alkylsulphonic, Z5 and Z6 being an alkyl Y is N or N+R, R being alkyl, aralkyl, aryl, alkanoic or alkylsulphonic Z1, Z2, Z3 and Z4 being independently H, Br, Cl, F, I, alkyl, aryl, alkoxy, perfluoroalkyl, nitro, cyano, carboxyl, sulphonyl, including the carboxyl or sulphonyl esters or amides and salts thereof.

Item Type: Patent
Subjects: F100 Chemistry
Department: Faculties > Health and Life Sciences > School of Life Sciences > Applied Sciences
Related URLs:
Depositing User: Linda Barlow
Date Deposited: 13 Mar 2012 11:18
Last Modified: 18 Aug 2015 09:22
URI: http://nrl.northumbria.ac.uk/id/eprint/5666

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