The application of an in vitro gastrointestinal extraction to assess the oral bioaccessibility of polycyclic aromatic hydrocarbons in soils from a former industrial site

Lorenzi, Damien, Entwistle, Jane, Cave, Mark, Wragg, Joanna and Dean, John (2012) The application of an in vitro gastrointestinal extraction to assess the oral bioaccessibility of polycyclic aromatic hydrocarbons in soils from a former industrial site. Analytica Chimica Acta, 735. pp. 54-61. ISSN 0003-2670

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Official URL: http://dx.doi.org/10.1016/j.aca.2012.05.030

Abstract

The total and bioaccessible concentration of 16 polycyclic aromatic hydrocarbons (PAHs) in soil from aformer industrial site was investigated. Typical total concentrations across the sampling sites ranged from 1.5 mg kg−1 for acenaphthylene up to 243 mg kg−1 for fluoranthene. The oral bioaccessibility of PAHs in soil was assessed using an in vitro gastrointestinal extraction (Fed Organic Estimation human Simulation Test, FOREhST method). The oral bioaccessibility data indicated that fluorene, phenanthrene, chrysene, indeno(1,2,3-cd)pyrene and dibenzo(a,h)anthracene had the highest % bioaccessible fraction (based on their upper 75th percentile values being >60%) while the other PAHs had lower % bioaccessible fractions (means ranging between 35 and 59%). Significantly lower bioaccessibilities were determined for naphthalene. With respect to method validation and inter-laboratory comparison, the total and bioaccessible concentrations of benzo(a)anthracene, benzo(b)anthracene, benzo(k)fluoranthene, benzo(a)pyrene, indeno(1,2,3-cd)pyrene and dibenzo(a,h)anthracene was compared to published data derived using the same samples. The total PAH concentrations at the site were compared with generic assessment criteria (GAC) using the residential land use scenario (with plant uptake at 6% soil organic matter). Concentrations of 7 of the PAHs investigated within the soils could lead to an unacceptable risk to human health at this site.

Item Type: Article
Uncontrolled Keywords: In vitro gastrointestinal extraction, health risk assessment Polycyclic aromatic hydrocarbons Gas chromatography–mass spectrometry
Subjects: F100 Chemistry
Department: Faculties > Health and Life Sciences > School of Life Sciences > Applied Sciences
Depositing User: Linda Barlow
Date Deposited: 20 Jun 2012 09:20
Last Modified: 10 Aug 2015 11:35
URI: http://nrl.northumbria.ac.uk/id/eprint/7714

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