McHale, Glen (2007) Surface free energy and microarray deposition technology. Analyst, 132 (3). pp. 192-195. ISSN 0003-2654
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Abstract
Microarray techniques use a combinatorial approach to assess complex biochemical interactions. The fundamental goal is simultaneous, large-scale experimentation analogous to the automation achieved in the semiconductor industry. However, microarray deposition inherently involves liquids contacting solid substrates. Liquid droplet shapes are determined by surface and interfacial tension forces, and flows during drying. This article looks at how surface free energy and wetting considerations may influence the accuracy and reliability of spotted microarray experiments.
| Item Type: | Article |
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| Uncontrolled Keywords: | droplets, wetting, microarray,contact angle |
| Subjects: | C100 Biology F100 Chemistry F300 Physics |
| Department: | Faculties > Engineering and Environment > Mathematics, Physics and Electrical Engineering |
| Depositing User: | Glen McHale |
| Date Deposited: | 23 Aug 2012 11:58 |
| Last Modified: | 17 Dec 2023 12:48 |
| URI: | https://nrl.northumbria.ac.uk/id/eprint/8318 |
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