The effect of carbohydrate ingestion on the Interleukin-6 response to a 90-minute run time trial

Robson-Ansley, Paula, Barwood, Martin, Eglin, Clare and Ansley, Les (2009) The effect of carbohydrate ingestion on the Interleukin-6 response to a 90-minute run time trial. International Journal of Sports Physiology and Performance, 4 (2). pp. 186-194. ISSN 1555-0265

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Abstract

Fatigue is a predictable outcome of prolonged physical activity; yet its biological cause remains uncertain. During exercise, a polypeptide messenger molecule interleukin- 6 (IL-6) is actively produced. Previously, it has been demonstrated that administration of recombinant IL-6 (rhIL-6) impairs 10-km run performance and heightened sensation of fatigue in trained runners. Both high carbohydrate diets and carbohydrate ingestion during prolonged exercise have a blunting effect on IL-6 levels postendurance exercise. We hypothesized that carbohydrate ingestion may improve performance during a prolonged bout of exercise as a consequence of a blunted IL-6 response. Seven recreationally trained fasted runners completed two 90-min time trials under CHO supplemented and placebo conditions in a randomized order. The study was of a double-blinded, placebo-controlled, cross-over study design. Distance covered in 90 min was significantly greater following exogenous carbohydrate ingestion compared with the placebo trial (19.13 ± 1.7 km and 18.29 ± 1.9 km, respectively, p = .0022). While postexercise IL-6 levels were significantly lower in the CHO trial compared with the placebo trial (5.3 ± 1.9 pg·mL?1and 6.6 ± 3.0 pg·mL?1, respectively; p = .0313), this difference was considered physiologically too small to mediate the improvement in time trial performance.

Item Type:	Article
Subjects:	C600 Sports Science
Department:	Faculties > Health and Life Sciences > Sport, Exercise and Rehabilitation
Related URLs:	Publisher
Depositing User:	EPrint Services
Date Deposited:	19 Mar 2010 15:42
Last Modified:	31 Jul 2021 08:38
URI:	http://nrl.northumbria.ac.uk/id/eprint/133

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