Characterization of a truncated lipoarabinomannan from the actinomycete Turicella otitidis

Gilleron, Martine, Garton, Natalie, Nigou, Jerome, Brando, Thérèse, Puzo, Germain and Sutcliffe, Iain (2005) Characterization of a truncated lipoarabinomannan from the actinomycete Turicella otitidis. Journal of Bacteriology, 187 (3). pp. 854-861. ISSN 0021-9193

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Lipoarabinomannan (LAM) lipoglycans have been characterized from a range of mycolic acid-containing actinomycetes and from the amycolate actinomycete Amycolatopsis sulphurea. To further understand the structural diversity of this family, we have characterized the lipoglycan of the otic commensal Turicella otitidis. T. otitidis LAM (TotLAM) lias been determined to consist of a mannosyl phosphatidylinositol anchor unit carrying an (α 1→6)-linked mannan core and substituted with terminal-arabinosyl branches. Thus, TotLAM has a novel truncated LAM structure. Using the human monocytic THP-1 cell line, it was found that TotLAM exhibited only minimal ability to induce tumor necrosis factor alpha. These findings contribute further to our understanding of actinomycete LAM diversity and allow further speculation as to the correlation between LAM structure and the immunomodulatory activities of these lipoglycans.

Item Type: Article
Subjects: C500 Microbiology
Department: Faculties > Health and Life Sciences > Applied Sciences
Depositing User: Becky Skoyles
Date Deposited: 03 Feb 2015 16:22
Last Modified: 12 Oct 2019 17:30

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