HCV and the hepatic lipid pathway as a potential treatment target

Bassendine, Margaret, Sheridan, David, Felmlee, Daniel, Bridge, Simon, Toms, Geoffrey and Neely, Robert Dermot (2011) HCV and the hepatic lipid pathway as a potential treatment target. Journal of Hepatology, 55 (6). pp. 1428-40. ISSN 0168-8278

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Atherosclerosis has been described as a liver disease of the heart. The liver is the central regulatory organ of lipid pathways but since dyslipidaemias are major contributors to cardiovascular disease and type 2 diabetes rather than liver disease, research in this area has not been a major focus for hepatologists. Virus-host interaction is a continuous co-evolutionary process involving the host immune system and viral escape mechanisms. One of the strategies HCV has adopted to escape immune clearance and establish persistent infection is to make use of hepatic lipid pathways. This review aims to: update the hepatologist on lipid metabolism; review the evidence that HCV exploits hepatic lipid pathways to its advantage; discuss approaches to targeting host lipid pathways as adjunctive therapy.

Item Type: Article
Uncontrolled Keywords: Antiviral agents; Lipoproteins; Cholesterol, VLDL; Triglycerides, Hepatitis C, Chronic
Subjects: A300 Clinical Medicine
Department: Faculties > Health and Life Sciences > Applied Sciences
Depositing User: Dr Simon Bridge
Date Deposited: 05 Oct 2016 15:16
Last Modified: 01 Aug 2021 05:38
URI: http://nrl.northumbria.ac.uk/id/eprint/27879

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