Role of miRNA-146a in the regulation of the innate immune response and cancer.

Williams, Andrew Evan, Perry, Mark, Moschos, Sterghios, Larner-Svensson, Hanna and Lindsay, Mark (2008) Role of miRNA-146a in the regulation of the innate immune response and cancer. Biochemical Society Transactions, 36 (6). pp. 1211-1215. ISSN 0300-5127

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Abstract

In mammalian cells, miRNAs (microRNAs) are the most abundant family of small non-coding RNAs that regulate mRNA translation through the RNA interference pathway. In general, it appears that the major function of miRNAs is in development, differentiation and homoeostasis, which is indicated by studies showing aberrant miRNA expression during the development of cancer. Interestingly, changes in the expression of miR-146a have been implicated in both the development of multiple cancers and in the negative regulation of inflammation induced via the innate immune response. Furthermore, miR-146a expression is driven by the transcription factor NF-kappaB (nuclear factor kappaB), which has been implicated as an important causal link between inflammation and carcinogenesis. In the present article, we review the evidence for a role of miR-146a in innate immunity and cancer and assess whether changes in miR-146a might link these two biological responses.

Item Type:	Article
Subjects:	B200 Pharmacology, Toxicology and Pharmacy C700 Molecular Biology, Biophysics and Biochemistry
Department:	Faculties > Health and Life Sciences > Applied Sciences
Depositing User:	Sterghios Moschos
Date Deposited:	24 Oct 2016 15:25
Last Modified:	12 Oct 2019 17:31
URI:	http://nrl.northumbria.ac.uk/id/eprint/28142

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