Community pharmacy lifestyle intervention to increase physical activity and improve cardiovascular health of men with prostate cancer: a phase II feasibility study

Lemanska, Agnieszka, Poole, Karen, Griffin, Bruce, Manders, Ralph, Saxton, John, Turner, Lauren, Wainwright, Joe and Faithfull, Sara (2019) Community pharmacy lifestyle intervention to increase physical activity and improve cardiovascular health of men with prostate cancer: a phase II feasibility study. BMJ Open, 9 (6). e025114. ISSN 2044-6055

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Objectives: To assess the feasibility and acceptability of a community pharmacy lifestyle intervention to improve physical activity and cardiovascular health of men with prostate cancer. To refine the intervention.

Design: Phase II feasibility study of a complex intervention.

Setting: Nine community pharmacies in UK.
Intervention: Community pharmacy teams were trained to deliver a health assessment including fitness, strength and anthropometric measures. A computer algorithm generated a personalised lifestyle prescription for a home-based programme accompanied by supporting resources. The health assessment was repeated 12 weeks later and support phone calls were provided at weeks 1 and 6.

Participants: 116 men who completed treatment for prostate cancer.

Outcome measures: The feasibility and acceptability of the intervention and the delivery model were assessed by evaluating study processes (rate of participant recruitment, consent, retention, and adverse events), by analysing delivery data and semi-structured interviews with participants and by focus groups with pharmacy teams. Physical activity (measured with accelerometry at baseline, three and six months) and patient reported outcomes (activation, dietary intake, quality of life) were evaluated. Change in physical activity was used to inform the sample size calculations for a future trial.

Results: Out of 403 invited men, 172 (43%) responded and 116 (29%) participated. Of these, 99 (85%) completed the intervention and 88 (76%) completed the six-month follow-up (attrition 24%). Certain components of the intervention were feasible and acceptable (e.g. community pharmacy delivery), while others were more challenging (e.g. fitness assessment) and will be refined for future studies. By three months, moderate to vigorous physical activity (MVPA) increased on average by 34 minutes (95%CI 6 to 62, P=0.018), but this was not sustained over six months.

Conclusions: The community pharmacy intervention was feasible and acceptable. Results are encouraging and warrant a definitive trial to assess the effectiveness of the refined intervention.

Item Type: Article
Uncontrolled Keywords: Prostate cancer, lifestyle intervention, physical activity, community pharmacy, survivorship, feasibility
Subjects: B100 Anatomy, Physiology and Pathology
B900 Others in Subjects allied to Medicine
L500 Social Work
Department: Faculties > Health and Life Sciences > Sport, Exercise and Rehabilitation
Depositing User: Becky Skoyles
Date Deposited: 02 Apr 2019 08:00
Last Modified: 01 Aug 2021 11:31

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