Hyperthermia Suppresses Post - In Vitro Proliferation and Tumor Growth in Murine Malignant Melanoma and Colon Carcinoma

Mantso, Theodora, Vasileiadis, Stavros, Lampri, Evangeli, Botaitis, Sotiris, Perente, Sebachedin, Simopoulos, Constantinos, Chlichlia, Katerina, Pappa, Aglaia and Panagiotidis, Mihalis (2019) Hyperthermia Suppresses Post - In Vitro Proliferation and Tumor Growth in Murine Malignant Melanoma and Colon Carcinoma. Anticancer Research, 39 (5). pp. 2307-2315. ISSN 0250-7005

Preview	Text 2307.full.pdf - Published Version Download (360kB) | Preview
	Text Mantso et al (revised).pdf - Accepted Version Restricted to Repository staff only Download (859kB) | Request a copy

Abstract

Background: Several studies have highlighted hyperthermia’s ability to enhance the effectiveness of radiation and chemotherapy in various in vitro and in vivo cancer models. Materials and Methods: In vivo murine models of malignant melanoma and colon carcinoma were utilized for demonstrating hyperthermia’s therapeutic effectiveness by examining levels of caspase 3, COX-2 and phospho-H2A.X (Ser139) as endpoints of apoptosis, proliferation and DNA damage respectively. Results: Hyperthermia induced in vitro cytotoxicity in malignant melanoma (B16-F10) and colon carcinoma (CT26) cell lines. In addition, it reduced post-in vitro proliferation and suppression of tumor growth by inducing the expression of caspase-3 and phospho-H2A.X (Ser139) while reducing the expression of COX-2 in both murine cancer models. Conclusion: Hyperthermia can exert therapeutic effectiveness against melanoma and colon carcinoma by inhibiting a number of critical cellular cascades including apoptosis, proliferation and DNA damage.

Actions (login required)

View Item

Downloads