Lauder, Kate, Masci, Domiziana, Toscani, Anita, Al Mekdad, Aya, Black, Gary, Brown, Nicola, Turner, Nicholas J., Luisi, Renzo and Castagnolo, Daniele (2019) A facile and regioselective multicomponent synthesis of chiral aryl-1,2-mercaptoamines in water followed by monoamine oxidase (MAO-N) enzymatic resolution. Organic & Biomolecular Chemistry, 17 (40). pp. 8982-8986. ISSN 1477-0520
|
Text
Lauderetal2019final.pdf - Accepted Version Download (562kB) | Preview |
Abstract
A facile microwave assisted three-component protocol allows the synthesis of chiral aryl-1,2-mercaptoamines in water in a few minutes with high yields, bypassing the use of toxic aziridine intermediates. The chiral 1,2-mercaptoamines were then deracemized through enzymatic resolution of the racemates using monoamine oxidase (MAO-N) biocatalysts.
| Item Type: | Article |
|---|---|
| Subjects: | C700 Molecular Biology, Biophysics and Biochemistry F100 Chemistry |
| Department: | Faculties > Health and Life Sciences > Applied Sciences |
| Depositing User: | Elena Carlaw |
| Date Deposited: | 31 Oct 2019 15:21 |
| Last Modified: | 31 Jul 2021 12:03 |
| URI: | http://nrl.northumbria.ac.uk/id/eprint/41326 |
Actions (login required)
 |
View Item |
Downloads
Downloads per month over past year
