Exercise Induces Peripheral Muscle But Not Cardiac Adaptations After Stroke: A Randomized Controlled Pilot Trial

Moore, Sarah A., Jakovljevic, Djordje G., Ford, Gary A., Rochester, Lynn and Trenell, Michael I. (2016) Exercise Induces Peripheral Muscle But Not Cardiac Adaptations After Stroke: A Randomized Controlled Pilot Trial. Archives of Physical Medicine and Rehabilitation, 97 (4). pp. 596-603. ISSN 0003-9993

[img]
Preview
Text
Moore 2016 peripheral and cardiac adaptations to exercise Archives.pdf - Published Version
Available under License Creative Commons Attribution 4.0.

Download (377kB) | Preview
Official URL: https://doi.org/10.1016/j.apmr.2015.12.018

Abstract

Objective
To explore the physiological factors affecting exercise-induced changes in peak oxygen consumption and function poststroke.

Design
Single-center, single-blind, randomized controlled pilot trial.

Setting
Community stroke services.

Participants
Adults (N=40; age>50y; independent with/without stick) with stroke (diagnosed >6mo previously) were recruited from 117 eligible participants. Twenty participants were randomized to the intervention group and 20 to the control group. No dropouts or adverse events were reported.

Interventions
Intervention group: 19-week (3times/wk) progressive mixed (aerobic/strength/balance/flexibility) community group exercise program. Control group: Matched duration home stretching program.

Main Outcome Measures
(1) Pre- and postintervention: maximal cardiopulmonary exercise testing with noninvasive (bioreactance) cardiac output measurements; and (2) functional outcome measures: 6-minute walk test; timed Up and Go test, and Berg Balance Scale.

Results
Exercise improved peak oxygen consumption (18±5 to 21±5mL/(kg⋅min); P<.01) and peak arterial-venous oxygen difference (9.2±2.7 to 11.4±2.9mL of O2/100mL of blood; P<.01), but did not alter cardiac output (17.2±4 to 17.7±4.2L/min; P=.44) or cardiac power output (4.8±1.3 to 5.0±1.35W; P=.45). A significant relation existed between change in peak oxygen consumption and change in peak arterial-venous oxygen difference (r=.507; P<.05), but not with cardiac output. Change in peak oxygen consumption did not strongly correlate with change in function.

Conclusions
Exercise induced peripheral muscle, but not cardiac output, adaptations after stroke. Implications for stroke clinical care should be explored further in a broader cohort.

Item Type: Article
Uncontrolled Keywords: Cardiac output, Exercise, Physical fitness, Rehabilitation, Stroke
Subjects: B300 Complementary Medicine
B900 Others in Subjects allied to Medicine
C600 Sports Science
Department: Faculties > Health and Life Sciences > Sport, Exercise and Rehabilitation
Depositing User: Elena Carlaw
Date Deposited: 12 Dec 2019 16:10
Last Modified: 12 Dec 2019 16:30
URI: http://nrl.northumbria.ac.uk/id/eprint/41731

Actions (login required)

View Item View Item

Downloads

Downloads per month over past year

View more statistics