The synthesis of trifluoromethylated N-nitroaryl-2-amino-1,3-dichloropropane derivatives and their evaluation as potential anti-cancer agents

Chappel, Lucy, Wong, Lai Chun, Leong, Chee-Onn, Mai, Chun-Wai, Meikle, Ian T., Stanforth, Stephen and Truong, Thang (2020) The synthesis of trifluoromethylated N-nitroaryl-2-amino-1,3-dichloropropane derivatives and their evaluation as potential anti-cancer agents. Bioorganic & Medicinal Chemistry Letters, 30 (4). p. 126910. ISSN 0960-894X

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Official URL: https://doi.org/10.1016/j.bmcl.2019.126910

Abstract

Six N-nitroaryl-2-amino-1,3-dichloropropane derivatives have been prepared and evaluated against 18 cancer cell lines and two non-cancerous cell lines. Analysis of cell viability data and IC50 values indicated that the presence of a trifluoromethyl group in the nitroaryl moiety is an important structural feature associated with the compounds’ cytotoxicities.

Item Type: Article
Uncontrolled Keywords: Nitroaromatic drugs, Anti-cancer agents, Trifluoromethylated drugs, Nitrogen mustards
Subjects: A300 Clinical Medicine
B200 Pharmacology, Toxicology and Pharmacy
B900 Others in Subjects allied to Medicine
Department: Faculties > Health and Life Sciences > Applied Sciences
Depositing User: Elena Carlaw
Date Deposited: 20 Jan 2020 14:59
Last Modified: 20 Jan 2020 15:00
URI: http://nrl.northumbria.ac.uk/id/eprint/41948

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