Integrating microfluidics and biosensing on a single flexible acoustic device using hybrid modes

Tao, Ran, Reboud, Julien, Torun, Hamdi, McHale, Glen, Dodd, Linzi, Wu, Qiang, Yang, Xin, Tao, Kai, Luo, Jing-ting, Todryk, Stephen and Fu, Richard (2020) Integrating microfluidics and biosensing on a single flexible acoustic device using hybrid modes. Lab on a Chip, 20 (5). pp. 1002-1011. ISSN 1473-0197

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Official URL: https://doi.org/10.1039/c9lc01189g

Abstract

Integration of microfluidics and biosensing functionalities on a single device holds promise in continuous health monitoring and disease diagnosis for point-of-care applications. However, the required functions of fluid handling and biomolecular sensing usually arise from different actuation mechanisms. In this work, we demonstrate that a single acoustofluidic device, based on a flexible thin film platform, is able to generate hybrid waves modes, which can be used for fluidic actuation (Lamb waves) and biosensing (thickness shear waves). On this integrated platform, we show multiple and sequential functions of mixing, transport and disposal of liquid volumes using Lamb waves, whilst the thickness bulk shear waves allow us to sense the chemotherapeutic Imatinib, using an aptamer-based strategy, as would be required for therapy monitoring. Upon binding, the conformation of the aptamer results in a change in coupled mass, which has been detected. This platform architecture has the potential to generate a wide range of simple sample-to-answer biosensing acoustofluidic devices.

Item Type: Article
Subjects: C700 Molecular Biology, Biophysics and Biochemistry
F100 Chemistry
F200 Materials Science
F300 Physics
H800 Chemical, Process and Energy Engineering
Department: Faculties > Engineering and Environment > Mathematics, Physics and Electrical Engineering
Faculties > Health and Life Sciences > Applied Sciences
Depositing User: Elena Carlaw
Date Deposited: 03 Feb 2020 16:13
Last Modified: 09 Apr 2020 09:15
URI: http://nrl.northumbria.ac.uk/id/eprint/42005

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