Factors affecting tear production and intraocular pressure in anesthetized chimpanzees (Pan troglodytes)

Milnes, Ellie Louise, Calvi, Thalita, Feltrer, Yedra, Drane, Aimee L., Howatson, Glyn, Shave, Rob E., Curry, Bryony A., Tremblay, Joshua C. and Williams, David Leonard (2020) Factors affecting tear production and intraocular pressure in anesthetized chimpanzees (Pan troglodytes). Journal of Zoo and Wildlife Medicine, 51 (3). pp. 687-690. ISSN 1042-7260

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Official URL: https://doi.org/10.1638/2020-0014

Abstract

Measurements of intraocular pressure (IOP) and tear production are key components of ophthalmic examination. Chimpanzees (Pan troglodytes) were anesthetized using either tiletamine-zolazepam (TZ; 2 mg/kg) combined with medetomidine (TZM; 0.02 mg/kg), or, TZ alone (6mg/kg). Tear production was lower (P = 0.03) with TZM (5.63 ± 6.22 mm/min; n = 16) than with TZ (11.13 ± 4.63 mm/min; n = 8). Mean IOP, measured using rebound tonometry in an upright body position (n = 8) was 18.74 ± 3.01 mm Hg, with no differences between right and left eyes. However, positioning chimpanzees in left lateral recumbency (n = 27) resulted in higher IOP in the dependent (left) eye (24.77 ± 4.49 mm Hg) compared to the nondependent (right) eye (22.27 ± 4.65 mm Hg) of the same animal (P < 0.0001). These data indicate medetomidine anesthesia markedly lowers tear production in chimpanzees, and that body position should be taken into consideration when performing rebound tonometry.

Item Type: Article
Subjects: C100 Biology
C300 Zoology
Department: Faculties > Health and Life Sciences > Sport, Exercise and Rehabilitation
Depositing User: Elena Carlaw
Date Deposited: 16 Mar 2020 09:10
Last Modified: 25 Nov 2020 14:00
URI: http://nrl.northumbria.ac.uk/id/eprint/42490

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