Phylogenomic characterisation of a novel corynebacterial species pathogenic to animals

Möller, Jens, Musella, Luca, Melnikov, Vyacheslav, Geißdörfe, Walter, Burkovski, Andreas and Sangal, Vartul (2020) Phylogenomic characterisation of a novel corynebacterial species pathogenic to animals. Antonie van Leeuwenhoek, 113 (8). pp. 1225-1239. ISSN 0003-6072

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Official URL: https://doi.org/10.1007/s10482-020-01430-5

Abstract

The genus Corynebacterium includes species of biotechnological, medical and veterinary importance. An atypical C. ulcerans strain, W25, was recently isolated from a case of necrotizing lymphadenitis in a wild boar. In this study, we have analysed the genome sequence of this strain and compared the phenotypic and virulence properties with other corynebacterial pathogens. Phylogenomic analyses revealed that strain W25 belongs to a novel species along with PO100/5 and KL1196. The latter strains were isolated from a pig and a roe deer, respectively; hence, this species appears to be associated to animals. The isolate W25 is likely a non-toxigenic tox gene bearing strain and may have compromised abilities to adhere to pharyngeal and laryngeal epithelial cells due to potential loss of the gene functions in spaBC and spaDEF pilus gene clusters. A number of corynebacterial virulence genes are present including pld encoding phospholipase D. Therefore, this strain may be able to cause severe invasive infections in animals and zoonotic infections in humans.

Item Type: Article
Uncontrolled Keywords: Corynebacterium ulceran, Diphtheria, Non-toxigeni, NTTB, Toxigenic, Virulence, Zoonotic
Subjects: C500 Microbiology
C700 Molecular Biology, Biophysics and Biochemistry
Department: Faculties > Health and Life Sciences > Applied Sciences
Depositing User: Elena Carlaw
Date Deposited: 01 Jun 2020 12:31
Last Modified: 17 Sep 2020 10:00
URI: http://nrl.northumbria.ac.uk/id/eprint/43281

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