Mathematical modeling of gonadotropin-releasing hormone signaling

Pratap, Amitesh, Garner, Kathryn, Voliotis, Margaritis, Tsaneva-Atanasova, Krasimira and McArdle, Craig A. (2017) Mathematical modeling of gonadotropin-releasing hormone signaling. Molecular and Cellular Endocrinology, 449. pp. 42-55. ISSN 0303-7207

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Official URL: https://doi.org/10.1016/j.mce.2016.08.022

Abstract

Gonadotropin-releasing hormone (GnRH) acts via G-protein coupled receptors on pituitary gonadotropes to control reproduction. These are Gq-coupled receptors that mediate acute effects of GnRH on the exocytotic secretion of luteinizing hormone (LH) and follicle-stimulating hormone (FSH), as well as the chronic regulation of their synthesis. GnRH is secreted in short pulses and GnRH effects on its target cells are dependent upon the dynamics of these pulses. Here we overview GnRH receptors and their signaling network, placing emphasis on pulsatile signaling, and how mechanistic mathematical models and an information theoretic approach have helped further this field.

Item Type: Article
Uncontrolled Keywords: GnRH, GPCR, NFAT, ERK, Mathematical modeling, Mutual information
Subjects: C500 Microbiology
G100 Mathematics
Department: Faculties > Health and Life Sciences > Applied Sciences
Depositing User: John Coen
Date Deposited: 03 Jun 2020 14:18
Last Modified: 03 Jun 2020 14:30
URI: http://nrl.northumbria.ac.uk/id/eprint/43335

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