Gallium Nitride: a versatile compound semiconductor as novel piezoelectric film for acoustic tweezer in manipulation of cancer cells

Sun, Chao, Wu, Fangda, Wallis, David, Shen, Ming Hong, Yuan, Fan, Wu, Jianzhong, Xie, Zhihua, Liang, Dongfang, Wang, Hanlin, Tickle, Rowan, Mikhaylov, Roman, Clayton, Aled, Zhou, You, Wu, Zhenlin, Fu, Richard, Xun, Wenpeng and Yang, Xin (2020) Gallium Nitride: a versatile compound semiconductor as novel piezoelectric film for acoustic tweezer in manipulation of cancer cells. IEEE Transactions on Electron Devices, 67 (8). pp. 3355-3361. ISSN 0018-9383

[img]
Preview
Text
TED_manuscript_final_submission.pdf - Accepted Version

Download (794kB) | Preview
Official URL: https://doi.org/10.1109/ted.2020.3002498

Abstract

Gallium nitride (GaN) is a compound semiconductor which has advantages to generate new functionalities and applications due to its piezoelectric, pyroelectric, and piezo-resistive properties. Recently, surface acoustic wave (SAW)-based acoustic tweezers were developed as an efficient and versatile tool to manipulate nano- and microparticles aiming for patterning, separating, and mixing biological and chemical components. Conventional piezoelectric materials to fabricate SAW devices such as lithium niobate suffer from its low thermal conductivity and incapability of fabricating multiphysical and integrated devices. This article piloted the development of a GaN-based acoustic tweezer (GaNAT) and its application in manipulating microparticles and biological cells. For the first time, the GaN SAW device was integrated with a microfluidic channel to form an acoustofluidic chip for biological applications. The GaNAT demonstrated its ability to work on high power (up to 10 W) with minimal cooling requirement while maintaining the device temperature below 32°C. Acoustofluidic modeling was successfully applied to numerically study and predict acoustic pressure field and particle trajectories within the GaNAT, which agree well with the experimental results on patterning polystyrene microspheres and two types of biological cells including fibroblast and renal tumor cells. The GaNAT allowed both cell types to maintain high viabilities of 84.5% and 92.1%, respectively.

Item Type: Article
Uncontrolled Keywords: Gallium nitride, surface acoustic wave, acoustic tweezer, cell manipulation
Subjects: F200 Materials Science
Department: Faculties > Engineering and Environment > Mathematics, Physics and Electrical Engineering
Depositing User: John Coen
Date Deposited: 15 Jun 2020 14:47
Last Modified: 27 Aug 2020 10:45
URI: http://nrl.northumbria.ac.uk/id/eprint/43453

Actions (login required)

View Item View Item

Downloads

Downloads per month over past year

View more statistics