The Gut Microbiome in Psychosis From Mice to Men: A Systematic Review of Preclinical and Clinical Studies

Kraeuter, Ann-Katrin, Phillips, Riana and Sarnyai, Zoltán (2020) The Gut Microbiome in Psychosis From Mice to Men: A Systematic Review of Preclinical and Clinical Studies. Frontiers in Psychiatry, 11. p. 799. ISSN 1664-0640

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Official URL: https://doi.org/10.3389/fpsyt.2020.00799

Abstract

The gut microbiome is rapidly becoming the focus of interest as a possible factor involved in the pathophysiology of neuropsychiatric disorders. Recent understanding of the pathophysiology of schizophrenia emphasizes the role of systemic components, including immune/inflammatory and metabolic processes, which are influenced by and interacting with the gut microbiome. Here we systematically review the current literature on the gut microbiome in schizophrenia-spectrum disorders and in their animal models. We found that the gut microbiome is altered in psychosis compared to healthy controls. Furthermore, we identified potential factors related to psychosis, which may contribute to the gut microbiome alterations. However, further research is needed to establish the disease-specificity and potential causal relationships between changes of the microbiome and disease pathophysiology. This can open up the possibility of. manipulating the gut microbiome for improved symptom control and for the development of novel therapeutic approaches in schizophrenia and related psychotic disorders.

Item Type: Article
Uncontrolled Keywords: gut microbiota, schizophrenia, early life events, inflammation, microbiota metabolites, stress
Subjects: A300 Clinical Medicine
B900 Others in Subjects allied to Medicine
C800 Psychology
Department: Faculties > Health and Life Sciences > Psychology
Depositing User: Elena Carlaw
Date Deposited: 20 Aug 2020 14:58
Last Modified: 20 Aug 2020 15:00
URI: http://nrl.northumbria.ac.uk/id/eprint/44146

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