Chronic Helminth Infection Perturbs the Gut-Brain Axis, Promotes Neuropathology, and Alters Behavior

Giacomin, Paul R., Kraeuter, Ann-Katrin, Albornoz, Eduardo A., Jin, Shuting, Bengtsson, Mia, Gordon, Richard, Woodruff, Trent M., Urich, Tim, Sarnyai, Zoltán and Soares Magalhães, Ricardo J. (2018) Chronic Helminth Infection Perturbs the Gut-Brain Axis, Promotes Neuropathology, and Alters Behavior. The Journal of Infectious Diseases, 218 (9). pp. 1511-1516. ISSN 0022-1899

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Official URL: https://doi.org/10.1093/infdis/jiy092

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Abstract
Helminth infections in children are associated with impaired cognitive development; however, the biological mechanisms for this remain unclear. Using a murine model of gastrointestinal helminth infection, we demonstrate that early-life exposure to helminths promotes local and systemic inflammatory responses and transient changes in the gastrointestinal microbiome. Behavioral and cognitive analyses performed 9-months postinfection revealed deficits in spatial recognition memory and an anxiety-like behavioral phenotype in worm-infected mice, which was associated with neuropathology and increased microglial activation within the brain. This study demonstrates a previously unrecognized mechanism through which helminth infections may influence cognitive function, via perturbations in the gut-immune-brain axis.

Item Type: Article
Uncontrolled Keywords: cognition, helminth, inflammation, microbiome
Subjects: B100 Anatomy, Physiology and Pathology
C500 Microbiology
C800 Psychology
Department: Faculties > Health and Life Sciences > Psychology
Depositing User: Elena Carlaw
Date Deposited: 20 Aug 2020 15:05
Last Modified: 20 Aug 2020 15:15
URI: http://nrl.northumbria.ac.uk/id/eprint/44147

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