Trauma and depressive symptomatology in middle-aged persons at high risk of dementia: the PREVENT Dementia Study

Ritchie, Karen, Carriere, Isabelle, Gregory, Sarah, Watermeyer, Tamlyn, Danso, Samuel, Su, Li, Ritchie, Craig and O'Brien, John (2021) Trauma and depressive symptomatology in middle-aged persons at high risk of dementia: the PREVENT Dementia Study. Journal of Neurology, Neurosurgery and Psychiatry, 92 (1). pp. 16-21. ISSN 0022-3050

[img]
Preview
Text
PREVENT_Dep_Trauma_Second_Revision_Unmarked.pdf - Accepted Version
Available under License Creative Commons Attribution Non-commercial 4.0.

Download (194kB) | Preview
Official URL: https://doi.org/10.1136/jnnp-2020-323823

Abstract

Objective Depression and trauma are associated with changes in brain regions implicated in Alzheimer’s disease. The present study examined associations between childhood trauma, depression, adult cognitive functioning and risk of dementia.

Methods Data from 378 participants in the PREVENT Dementia Study aged 40–59 years. Linear and logistic models were used to assess associations between childhood trauma, depression, dementia risk, cognitive test scores and hippocampal volume.

Results Childhood trauma was associated with depression and reduced hippocampal volume but not current cognitive function or dementia risk. Poorer performance on a delayed face/name recall task was associated with depression. Childhood trauma was associated with lower hippocampal volume however poorer cognitive performance was mediated by depression rather than structural brain differences.

Conclusion Depressive symptomatology may be associated with dementia risk via multiple pathways, and future studies should consider subtypes of depressive symptomatology when examining its relationship to dementia.

Item Type: Article
Subjects: C800 Psychology
Department: Faculties > Health and Life Sciences > Psychology
Depositing User: Ellen Cole
Date Deposited: 25 Sep 2020 11:07
Last Modified: 12 Jan 2021 11:15
URI: http://nrl.northumbria.ac.uk/id/eprint/44296

Actions (login required)

View Item View Item

Downloads

Downloads per month over past year

View more statistics