Martin, Tristan, Twomey, Rosie, Medysky, Mary E., Temesi, John, Culos-Reed, S. Nicole and Millet, Guillaume Y. (2020) The Relationship between Fatigue and Actigraphy-Derived Sleep and Rest-Activity Patterns in Cancer Survivors. Current Oncology. ISSN 1198-0052 (In Press)
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Abstract
Background Cancer-related fatigue can continue long after curative cancer treatment. The aim of this study was to investigate sleep and rest-activity cycles in fatigued and non-fatigued cancer survivors. We hypothesized that sleep and rest-activity cycles would be more disturbed in people experiencing clinically-relevant fatigue, and that objective measures of sleep would be associated with the severity of fatigue in cancer survivors. Methods: Cancer survivors (n=87) completed a 14-day wrist actigraphy measurement for the estimation of sleep and rest-activity cycles. Fatigue was measured using the Functional Assessment of Chronic Illness Therapy-Fatigue Scale (FACIT-F). Participants were dichotomised into two groups using a previously validated score (fatigued n=51 and non-fatigued n=36). Perception of sleep was measured using the Insomnia Severity Index (ISI). Results: FACIT-F score was correlated with wake after sleep onset (r =-0.28; p = 0.010), sleep efficiency (r=0.26; p=0.016), sleep onset latency (r=-0.31; p=0.044) and ISI score (r=-0.56; p <0.001). The relative amplitude of the rest-activity cycles was lower in the fatigued vs. non-fatigued group (p=0.017; d=0.58). Conclusions: After treatment for cancer, the severity of cancer-related fatigue is correlated with specific objective measures of sleep, and there is evidence of rest-activity cycle disruption in people experiencing clinically-relevant fatigue.
Item Type: | Article |
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Uncontrolled Keywords: | insomnia, rest-activity cycle, actigraphy, cancer-related fatigue |
Subjects: | B100 Anatomy, Physiology and Pathology B900 Others in Subjects allied to Medicine C600 Sports Science |
Department: | Faculties > Health and Life Sciences > Sport, Exercise and Rehabilitation |
Depositing User: | Rachel Branson |
Date Deposited: | 27 Oct 2020 09:50 |
Last Modified: | 28 Jan 2021 16:45 |
URI: | http://nrl.northumbria.ac.uk/id/eprint/44597 |
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