Dietary Wheat Amylase Trypsin Inhibitors Impact Alzheimer’s Disease Pathology in 5xFAD Model Mice

dos Santos Guilherme, Malena, Zevallos Herencia, Victor, Pesi, Aline, Stoye, Nicolai M., Nguyen, Vu Thu Thuy, Radyushkin, Konstantin, Schwiertz, Andreas, Schmitt, Ulrich, Schuppan, Detlef and Endres, Kristina (2020) Dietary Wheat Amylase Trypsin Inhibitors Impact Alzheimer’s Disease Pathology in 5xFAD Model Mice. International Journal of Molecular Sciences, 21 (17). p. 6288. ISSN 1422-0067

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Official URL: https://doi.org/10.3390/ijms21176288

Abstract

Wheat amylase trypsin inhibitors (ATIs) represent a common dietary protein component of gluten-containing cereals (wheat, rye, and barley). They act as toll-like receptor 4 ligands, and are largely resistant to intestinal proteases, eliciting a mild inflammatory response within the intestine after oral ingestion. Importantly, nutritional ATIs exacerbated inflammatory bowel disease and features of fatty liver disease and the metabolic syndrome in mice. For Alzheimer’s disease (AD), both inflammation and altered insulin resistance are major contributing factors, impacting onset as well as progression of this devastating brain disorder in patients. In this study, we evaluated the impact of dietary ATIs on a well-known rodent model of AD (5xFAD). We assessed metabolic, behavioral, inflammatory, and microbial changes in mice consuming different dietary regimes with and without ATIs, consumed ad libitum for eight weeks. We demonstrate that ATIs, with or without a gluten matrix, had an impact on the metabolism and gut microbiota of 5xFAD mice, aggravating pathological hallmarks of AD. If these findings can be translated to patients, an ATI-depleted diet might offer an alternative therapeutic option for AD and warrants clinical intervention studies.

Item Type: Article
Uncontrolled Keywords: Aβ, ATI, 5xFAD, gluten, inflammation, intestine, microbiota, plaque, TLR4, wheat sensitivity
Subjects: B100 Anatomy, Physiology and Pathology
B200 Pharmacology, Toxicology and Pharmacy
Department: Faculties > Health and Life Sciences > Applied Sciences
Depositing User: John Coen
Date Deposited: 16 Nov 2020 14:41
Last Modified: 16 Nov 2020 14:45
URI: http://nrl.northumbria.ac.uk/id/eprint/44770

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