Cancer prevention through weight control—where are we in 2020?

Anderson, Annie S., Renehan, Andrew G., Saxton, John, Bell, Joshua, Cade, Janet, Cross, Amanda J., King, Angela, Riboli, Elio, Sniehotta, Falko, Treweek, Shaun and Martin, Richard M. (2020) Cancer prevention through weight control—where are we in 2020? British Journal of Cancer. ISSN 0007-0920 (In Press)

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Growing data from epidemiological studies highlight the association between excess body fat and cancer incidence, but good indicative evidence demonstrates that intentional weight loss, as well as increasing physical activity, offers much promise as a cost-effective approach for reducing the cancer burden. However, clear gaps remain in our understanding of how changes in body fat or levels of physical activity are mechanistically linked to cancer, and the magnitude of their impact on cancer risk. It is important to investigate the causal link between programmes that successfully achieve short-term modest weight loss followed by weight-loss maintenance and cancer incidence. The longer-term impact of weight loss and duration of overweight and obesity on risk reduction also need to be fully considered in trial design. These gaps in knowledge need to be urgently addressed to expedite the development and implementation of future cancer-control strategies. Comprehensive approaches to trial design, Mendelian randomisation studies and data-linkage opportunities offer real possibilities to tackle current research gaps. In this paper, we set out the case for why non-pharmacological weight-management trials are urgently needed to support cancer-risk reduction and help control the growing global burden of cancer.

Item Type: Article
Uncontrolled Keywords: Cancer prevention, Lifestyle modification, Public health
Subjects: A100 Pre-clinical Medicine
Department: Faculties > Health and Life Sciences > Sport, Exercise and Rehabilitation
Depositing User: John Coen
Date Deposited: 18 Dec 2020 13:25
Last Modified: 12 Jan 2021 11:19

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