Cancer survivorship, excess body fatness and weight-loss intervention—where are we in 2020?

Anderson, Annie S., Martin, Richard M., Renehan, Andrew G., Cade, Janet, Copson, Ellen R., Cross, Amanda J., Grimmett, Chloe, Keaver, Laura, King, Angela, Riboli, Elio, Shaw, Clare, Saxton, John and On behalf of the UK NIHR Cancer and Nutrition Collaboration (Pop, (2020) Cancer survivorship, excess body fatness and weight-loss intervention—where are we in 2020? British Journal of Cancer. ISSN 0007-0920 (In Press)

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Official URL: https://doi.org/10.1038/s41416-020-01155-2

Abstract

Earlier diagnosis and more effective treatments mean that the estimated number of cancer survivors in the United Kingdom is expected to reach 4 million by 2030. However, there is an increasing realisation that excess body fatness (EBF) is likely to influence the quality of cancer survivorship and disease-free survival. For decades, the discussion of weight management in patients with cancer has been dominated by concerns about unintentional weight loss, low body weight and interventions to increase weight, often re-enforced by the existence of the obesity paradox, which indicates that high body weight is associated with survival benefits for some types of cancer. However, observational evidence provides strong grounds for testing the hypothesis that interventions for promoting intentional loss of body fat and maintaining skeletal muscle in overweight and obese cancer survivors would bring important health benefits in terms of survival outcomes and long-term impact on treatment-related side effects. In this paper, we outline the need for studies to improve our understanding of the health benefits of weight-loss interventions, such as hypocaloric healthy-eating plans combined with physical activity. In particular, complex intervention trials that are pragmatically designed are urgently needed to develop effective, clinically practical, evidence-based strategies for reducing EBF and optimising body composition in people living with and beyond common cancers.

Item Type: Article
Additional Information: Funding information: This work was supported by the NIHR Cancer and Nutrition Collaboration. The views expressed are those of the author(s) and not necessarily those of the NIHR or the Department of Health and Social Care Funding. R.M.M. is supported by a Cancer Research UK programme grant (C18281/A19169) and by the National Institute for Health Research (NIHR) Bristol Biomedical Research Centre. The National Institute for Health Research (NIHR) Bristol Biomedical Research Centre is funded by the National Institute for Health Research and is a partnership between University Hospitals Bristol NHS Trust and the University of Bristol. The views expressed are those of the author(s) and not necessarily those of the NIHR or the Department of Health and Social Care. A.G.R. is supported by the Manchester NIHR Biomedical Research Centre (IS-BRC-1215-20007). C.S. is partly funded by the National Institute for Health Research (NIHR) Biomedical Research Centre at The Royal Marsden NHS Foundation Trust and the Institute of Cancer Research, London.
Uncontrolled Keywords: Cancer prevention, Risk factors, Weight management
Subjects: A300 Clinical Medicine
B900 Others in Subjects allied to Medicine
Department: Faculties > Health and Life Sciences > Sport, Exercise and Rehabilitation
Depositing User: John Coen
Date Deposited: 18 Dec 2020 13:56
Last Modified: 04 Mar 2021 10:20
URI: http://nrl.northumbria.ac.uk/id/eprint/45059

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