Functional relevance of resistance training-induced neuroplasticity in health and disease

Hortobágyi, Tibor, Granacher, Urs, Fernandez-del-Olmo, Miguel, Howatson, Glyn, Manca, Andrea, Deriu, Franca, Taube, Wolfgang, Gruber, Markus, Márquez, Gonzalo and Colomer-Poveda, David (2021) Functional relevance of resistance training-induced neuroplasticity in health and disease. Neuroscience & Biobehavioral Reviews, 122. pp. 79-91. ISSN 0149-7634

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Official URL: https://doi.org/10.1016/j.neubiorev.2020.12.019

Abstract

Repetitive, monotonic, and effortful voluntary muscle contractions performed for just a few weeks, i.e., resistance training, can substantially increase maximal voluntary force in the practiced task and can also increase gross motor performance. The increase in motor performance is often accompanied by neuroplastic adaptations in the central nervous system. While historical data assigned functional relevance to such adaptations induced by resistance training, this claim has not yet been systematically and critically examined in the context of motor performance across the lifespan in health and disease. A review of muscle activation, brain and peripheral nerve stimulation, and imaging data revealed that increases in motor performance and neuroplasticity tend to be uncoupled, making a mechanistic link between neuroplasticity and motor performance inconclusive. We recommend new approaches, including causal mediation analytical and hypothesis-driven models to substantiate the functional relevance of resistance training-induced neuroplasticity in the improvements of gross motor function across the lifespan in health and disease.

Item Type: Article
Uncontrolled Keywords: Maximal voluntary contraction (MVC), Strength training, Electromyography (EMG), Transcranial magnetic brain stimulation (TMS), Electroencephalography (EEG), Functional magnetic resonance imaging (fMRI), Athletic performance, Aging, Parkinson’s disease, Multiple Sclerosis, Stroke, Directed Acyclic Graphs, Causal Mediation Analysis
Subjects: B900 Others in Subjects allied to Medicine
C600 Sports Science
Department: Faculties > Health and Life Sciences > Sport, Exercise and Rehabilitation
Depositing User: John Coen
Date Deposited: 04 Jan 2021 10:30
Last Modified: 03 Feb 2021 16:43
URI: http://nrl.northumbria.ac.uk/id/eprint/45069

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