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Emily and Neaverson, Alexandra S. (2021) Evaluating the Effects of SARS-CoV-2 Spike Mutation D614G on Transmissibility and Pathogenicity. Cell, 184. pp. 1-12. ISSN 0092-8674
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Abstract
Global dispersal and increasing frequency of the SARS-CoV-2 spike protein variant D614G are suggestive of a selective advantage but may also be due to a random founder effect. We investigate the hypothesis for positive selection of spike D614G in the United Kingdom using more than 25,000 whole genome SARS-CoV-2 sequences. Despite the availability of a large dataset, well represented by both spike 614 variants, not all approaches showed a conclusive signal of positive selection. Population genetic analysis indicates that 614G increases in frequency relative to 614D in a manner consistent with a selective advantage. We do not find any indication that patients infected with the spike 614G variant have higher COVID-19 mortality or clinical severity, but 614G is associated with higher viral load and younger age of patients. Significant differences in growth and size of 614G phylogenetic clusters indicate a need for continued study of this variant.
Item Type: | Article |
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Uncontrolled Keywords: | COVID-19, SARS-CoV-2, evolution, founder effect, epidemiology, spike |
Subjects: | A300 Clinical Medicine B100 Anatomy, Physiology and Pathology C500 Microbiology C700 Molecular Biology, Biophysics and Biochemistry |
Department: | Faculties > Health and Life Sciences > Applied Sciences |
Depositing User: | Elena Carlaw |
Date Deposited: | 04 Jan 2021 15:09 |
Last Modified: | 04 Jan 2021 15:15 |
URI: | http://nrl.northumbria.ac.uk/id/eprint/45077 |
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