Effects of Saffron Extract Supplementation on Mood, Well-Being, and Response to a Psychosocial Stressor in Healthy Adults: A Randomized, Double-Blind, Parallel Group, Clinical Trial

Jackson, Philippa, Forster, Joanne, Khan, Julie, Pouchieu, Camille, Dubreuil, Séverine, Gaudout, David, Moras, Benjamin, Pourtau, Line, Joffre, Florent, Vaysse, Carole, Bertrand, Karène, Abrous, Hélène, Vauzour, David, Brossaud, Julie, Corcuff, Jean Benoit, Capuron, Lucile and Kennedy, David (2021) Effects of Saffron Extract Supplementation on Mood, Well-Being, and Response to a Psychosocial Stressor in Healthy Adults: A Randomized, Double-Blind, Parallel Group, Clinical Trial. Frontiers in Nutrition, 7. p. 606124. ISSN 2296-861X

[img]
Preview
Text
fnut-07-606124.pdf - Published Version
Available under License Creative Commons Attribution 4.0.

Download (1MB) | Preview
Official URL: https://doi.org/10.3389/fnut.2020.606124

Abstract

Anxiety, stress, and low mood are closely related and may contribute to depressive symptoms. Among non-pharmacological solutions to improve subclinical mood symptoms and resilience to stress, natural products such as saffron—identified as promising following preliminary beneficial effects in major depressive disorder—represent a relevant strategy. This study aimed to assess the efficacy of 8 weeks' supplementation with 30 mg standardized saffron extract on emotional well-being in healthy adults with subclinical feelings of low mood and anxiety and/or stress and evaluate the acute effect of saffron in response to a lab-based psychosocial stressor. The study adopted a double-blind, randomized, parallel groups design in which 56 healthy male and female individuals (18–54 years) received either a saffron extract or a placebo for 8 weeks. Chronic effects of saffron on subjective anxiety, stress, and depressive feelings were assessed using a questionnaire battery [including Profile of Mood State-2, (POMS)] and acute effects in response to a lab-based psychosocial stressor were measured through psychological and physiological parameters. Urinary crocetin levels were quantified. Participants who received the saffron extract reported reduced depression scores and improved social relationships at the end of the study. Urinary crocetin levels increased significantly with saffron supplementation and were correlated with change in depression scores. The typical stress-induced decrease in heart rate variability (HRV) during exposure to the stressor was attenuated following acute saffron intake. Saffron extract appears to improve subclinical depressive symptoms in healthy individuals and may contribute to increased resilience against the development of stress-related psychiatric disorders.

Item Type: Article
Additional Information: Clinical trials number: NCT03639831.
Uncontrolled Keywords: saffron, depression, anxiety, heart rate variability, crocetin
Subjects: B400 Nutrition
C800 Psychology
Department: Faculties > Health and Life Sciences > Psychology
Depositing User: John Coen
Date Deposited: 15 Feb 2021 10:49
Last Modified: 15 Feb 2021 11:00
URI: http://nrl.northumbria.ac.uk/id/eprint/45426

Actions (login required)

View Item View Item

Downloads

Downloads per month over past year

View more statistics