An Enhanced Tilted-Angle Acoustofluidic Chip for Cancer Cell Manipulation

Wu, Fangda, Shen, Ming Hong, Yang, Jian, Wang, Hanlin, Mikhaylov, Roman, Clayton, Aled, Qin, Xinghua, Sun, Chao, Xie, Zhihua, Cai, Meng, Wei, Jun, Liang, Dongfang, Yuan, Fan, Wu, Zhenlin, Fu, Richard, Yang, Zhiyong, Sun, Xianfang, Tian, Liangfei and Yang, Xin (2021) An Enhanced Tilted-Angle Acoustofluidic Chip for Cancer Cell Manipulation. IEEE Electron Device Letters, 42 (4). pp. 577-580. ISSN 0741-3106

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Official URL: https://doi.org/10.1109/led.2021.3062292

Abstract

In recent years, surface acoustic wave (SAW) devices have demonstrated great potentials and increasing applications in the manipulation of nano- and microparticles including biological cells with the advantages of label-free, high sensitivity and accuracy. In this letter, we introduce a novel tilted-angle SAW devices to optimise the acoustic pressure inside a microchannel for cancer-cell manipulation. The SAW generation and acoustic radiation force are improved by seamlessly patterning electrodes in the space surrounding the microchannel. Comparisons between this novel SAW device and a conventional device show a 32% enhanced separation efficiency while the input power, manufacturing cost and fabrication effort remain the same. Effective separation of HeLa cancer cells from peripheral blood mononuclear cells is demonstrated. This novel SAW device has the advantages in minimizing device power consumption, lowering component footprint and increasing device density.

Item Type: Article
Additional Information: Funding information: This work was supported in part by the Natural Science Basic Research Program of Shaanxi Province under Grant 2020JQ-233, in part by the Fundamental Scientific Research of Central Universities under Grant 3102017OQD116, in part by the Engineering and Physical Sciences Research Council (EPSRC) under Grant EP/P002803/1 and Grant EP/P018998/1, and in part by the Royal Society under Grant IEC/NSFC/170142 and Grant IE161019.
Uncontrolled Keywords: Surface acoustic wave (SAW), cancer cells, acoustofluidics, acoustic separation
Subjects: B800 Medical Technology
H600 Electronic and Electrical Engineering
Department: Faculties > Engineering and Environment > Mathematics, Physics and Electrical Engineering
Depositing User: John Coen
Date Deposited: 08 Mar 2021 09:04
Last Modified: 31 May 2021 14:38
URI: http://nrl.northumbria.ac.uk/id/eprint/45632

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