Trajectories of pain over 6 years in early Parkinson’s disease: ICICLE-PD

Naisby, Jenni, Lawson, Rachael A., Galna, Brook, Alcock, Lisa, Burn, David J., Rochester, Lynn and Yarnall, Alison J. (2021) Trajectories of pain over 6 years in early Parkinson’s disease: ICICLE-PD. Journal of Neurology. ISSN 0340-5354 (In Press)

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Pain is a common non-motor symptom in Parkinson’s disease (PD), affecting up to 85% of patients. The frequency and stability of pain over time has not been extensively studied. There is a paucity of high-quality studies investigating pain management in PD. To develop interventions, an understanding of how pain changes over the disease course is required.

One hundred and fifty-four participants with early PD and 99 age-and-sex-matched controls were recruited as part of a longitudinal study (Incidence of Cognitive Impairment in Cohorts with Longitudinal Evaluation in PD, ICICLE-PD). Pain data were collected at 18-month intervals over 72 months in both groups using the Nonmotor Symptom Questionnaire (NMSQ), consisting of a binary yes/no response. Two questions from the Parkinson’s Disease Questionnaire (PDQ-39) were analysed for the PD group only.

Unexplained pain was common in the PD group and occurred more frequently than in age-matched controls. ‘Aches and pains’ occurred more frequently than ‘cramps and muscle spasms’ at each time point (p < 0.001) except 54 months.

This study shows that pain is prevalent even in the early stages of PD, yet the frequency and type of pain fluctuates as symptoms progress. People with PD should be asked about their pain at clinical consultations and given support with describing pain given the different ways this can present.

Item Type: Article
Additional Information: Funding information: RAL is supported by a Janet Owens Parkinson’s UK Senior Research Fellowship (F-1801). LR receives research funding from NIHR, MRC, EU, Stroke Association, GE Healthcare, Parkinson’s UK, Dunhill Medical Trust, Cure Parkinson’s Trust, New Zealand Health Research Council. AJY has received funding from Parkinson’s UK, Dunhill Medical trust, EU IMI, NIHR, Michael J Fox Foundation, and Weston Brain Institute for project grants. She has received honoraria/funding for educational events from Britannia, UCB, Abbvie, GSK, Teva-Lundbeck, and Genus. JN, BG, LA, and DJB have nothing to declare. This study was funded by Parkinson's UK (J-0802, G-1301, G-1507).
Uncontrolled Keywords: Parkinson’s disease, Pain, Longitudinal
Subjects: B100 Anatomy, Physiology and Pathology
Department: Faculties > Health and Life Sciences > Sport, Exercise and Rehabilitation
Depositing User: Elena Carlaw
Date Deposited: 05 May 2021 10:31
Last Modified: 31 Jul 2021 16:18

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