Flexible and Bendable Acoustofluidics for Particle and Cell Patterning

Maramizonouz, Sadaf, Tao, Xiang, Rahmati, Mohammad, Jia, Changfeng, Tao, Ran, Torun, Hamdi, Zheng, Tengfei, Jin, Hao, Dong, Shurong, Luo, Jikui and Fu, Richard (2021) Flexible and Bendable Acoustofluidics for Particle and Cell Patterning. International Journal of Mechanical Sciences, 202 (203). p. 106536. ISSN 0020-7403

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Official URL: https://doi.org/10.1016/j.ijmecsci.2021.106536

Abstract

Surface acoustic wave (SAW) based microfluidic devices provide active techniques to manipulate fluid and particles, which can be used for precise and controllable patterning of microparticles and biological cells, with a high efficiency in a non-invasive and contact-free manner. This paper investigates flexible and bendable SAW microfluidic devices and explores the effects of bending and twisting of SAW devices on microparticle and cell patterning, using both experimental and numerical modelling. We showed that bending flexible SAW devices changes the distribution of particle pattern lines significantly. In devices with concave bending the particle pattern lines converge towards the centre of the curvature, whereas for devices with convex bending, they diverge away from it. Comparing the particle patterning using Lamb and Rayleigh wave devices with concave bending, we found that particle alignment is more efficient in the flexural mode Lamb wave device, whereas for the devices with convex bending, the particle patterning is more clear and regular when Rayleigh waves are used. We further investigated the effects of twisting the flexible SAW devices and observed that the particles are patterned into lines parallel to the deformed interdigital transducers (IDTs). We finally patterned yeast cells using our flexible SAW devices, and demonstrated the possibility of using our flexible acoustofluidic device for biomechanical systems such as body conforming technologies, wearable bio-sensors, and flexible point-of-care devices for personalized health monitoring.

Item Type: Article
Additional Information: Funding information: The UK Engineering and Physical Sciences Research Council (EPSRC) Grants (EP/P018998/1), Special Interest Group of Acoustofluidics from UK Fluids Network (EP/N032934/1), International Exchange Grant (IEC/NSFC/201078) through Royal Society and the National Natural Science Foundation of China, and EPSRC NetworkPlus in Digitalised Surface Manufacturing EP/S036180/1.
Uncontrolled Keywords: Flexible Acoustofluidics, Particle and Cell Patterning, Thin Film SAW Devices
Subjects: F200 Materials Science
G900 Others in Mathematical and Computing Sciences
Department: Faculties > Engineering and Environment > Mathematics, Physics and Electrical Engineering
Faculties > Engineering and Environment > Mechanical and Construction Engineering
Depositing User: John Coen
Date Deposited: 20 May 2021 09:16
Last Modified: 31 Jul 2021 10:47
URI: http://nrl.northumbria.ac.uk/id/eprint/46226

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