Resistance Training improves Nerve Conduction and Arterial Stiffness in Older Adults with Diabetic Distal Symmetrical Polyneuropathy: A Randomized Controlled Trial

Gholami, Farhad, Khaki, Raziyek, Mirzaei, Batool and Howatson, Glyn (2021) Resistance Training improves Nerve Conduction and Arterial Stiffness in Older Adults with Diabetic Distal Symmetrical Polyneuropathy: A Randomized Controlled Trial. Experimental Gerontology, 153. p. 111481. ISSN 0531-5565

[img] Text
Manuscript_R2_Draft_3.pdf - Accepted Version
Restricted to Repository staff only until 17 July 2022.
Available under License Creative Commons Attribution Non-commercial No Derivatives 4.0.

Download (315kB) | Request a copy
Official URL: https://doi.org/10.1016/j.exger.2021.111481

Abstract

Diabetes is the main cause of peripheral neuropathy where older patients are at increased risk of diabetic distal symmetrical polyneuropathy (DSPN) due to age-related nerve degeneration and vascular changes. The aim of the study was to investigate the effect of resistance training on nerve conduction, measures of neuropathy and arterial stiffness in older patients with DSPN. In a randomized controlled trial, thirty-four older adults with type-2 diabetes and peripheral neuropathy were enrolled and randomly assigned to experimental and control groups. The experimental group carried out circuit resistance training (1-3 rounds, 11 exercises, 10-15 reps, 50-60 of 1RM, 3 times per week) for 12 weeks. Measurements were performed at baseline and 48 h after the intervention. Measures of DSPN including Michigan neuropathy screening instrument (MNSI), Michigan diabetic neuropathy score (MDNS), motor nerve action potential amplitude (APA), sensory and motor nerve conduction velocity (NCV) improved following intervention (p<0.001, p = 0.001, p = 0.034, p = 0.001, and p = 0.001, respectively). Sensory APA did not change after the intervention (p = 0.139). Cardio-ankle vascular index (CAVI) and ankle-brachial index (ABI) improved in the experimental group compared with the control group (p = 0.014 and p = 0.033, respectively). In addition, HbA1C decreased following the 12-week resistance training program (p=0.002). Older adults with DSPN respond positively to resistance training by improved neuropathy symptoms, nerve conduction, arterial stiffness and glucose regulation. Resistance training offers a positive intervention that can abate the progression of DSPN in older adults.

Item Type: Article
Additional Information: Funding information: This work was supported by research department of Shahrood University of Technology.
Uncontrolled Keywords: Exercise training, Arterial stiffness, Polyneuropathy, Nerve conduction, Type-2 diabetes mellitus
Subjects: B100 Anatomy, Physiology and Pathology
C600 Sports Science
Department: Faculties > Health and Life Sciences > Sport, Exercise and Rehabilitation
Depositing User: Rachel Branson
Date Deposited: 14 Jul 2021 13:06
Last Modified: 03 Aug 2021 13:45
URI: http://nrl.northumbria.ac.uk/id/eprint/46675

Actions (login required)

View Item View Item

Downloads

Downloads per month over past year

View more statistics