Ti3C2Tx MXene-Au nanoparticles doped polyimide thin film as a transducing bioreceptor for real-time acoustic detection of carcinoembryonic antigen

Jandas, P. J., Prabakaran, K., Luo, Jingting, Fu, Chen, Fu, Richard and Holaday, Derry (2021) Ti3C2Tx MXene-Au nanoparticles doped polyimide thin film as a transducing bioreceptor for real-time acoustic detection of carcinoembryonic antigen. Sensors and Actuators A: Physical, 331. p. 112998. ISSN 0924-4247

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Official URL: https://doi.org/10.1016/j.sna.2021.112998

Abstract

Ti3C2Tx MXene was synthesized and the 2D layers were hybridized with Au nanoparticle(AuNP) through the in-situ method. The study was successfully prepared MXene 2D layerand the same was TEM captured as well. Polyimide/MXene-AuNP (PI/Mxene-AuNP)transducing conducting nanocomposite thin film was synthesized and evaluated the newmaterial’s capability to use as a transducing thin film for biosensing application. Thebioreceptor was prepared on the delay line area of the SAW device by covalentlyimmobilizing mouse monoclonal antibody of carcinoembryonic antigen (CEA) through thethioglycolic acid arm linker mechanism. Immunoassay analysis has suggested that thebiosensor responds linearly with the increase in the concentration of the CEA sample. Thelimit of detection was observed at 0.001 ng/ml. The insertion loss of the bioreceptor wasrecorded at 10 dB, which also mattered in the high sensitivity of the biosensor. The biosensorhas shown excellent selectivity within the environment of other common tumour markers andwas stable for 75 days under periodical testing conditions. Clinical serum samples wereanalyzed successfully and the results were compared with values obtained through the ELISAmethod.

Item Type: Article
Additional Information: Funding information: We express our sincere gratitude to our funding agencies Research and Development Program of Guangdong Province (Grant no. 2020B0101040002), Key Research Program of Education Department for Guangdong Province (Grant no. 2020ZDZX2007), Shenzhen Science & Technology Project (Grant nos. JCYJ20180507182106754, JCYJ2018050718243957, JCYJ20180305124317872, GJHZ20200073109583010).
Uncontrolled Keywords: MXene, Ti3C2Tx, AuNP, Biosensor, CEA, SAW
Subjects: F200 Materials Science
F300 Physics
Department: Faculties > Engineering and Environment > Mathematics, Physics and Electrical Engineering
Depositing User: John Coen
Date Deposited: 26 Jul 2021 12:51
Last Modified: 24 Aug 2021 16:16
URI: http://nrl.northumbria.ac.uk/id/eprint/46757

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