Fourth Generation Glucose Sensors Composed of Copper Nanostructures for Diabetes Management: A Critical Review

Awan, Tasbiha, Naikoo, Gowhar A., Salim, Hiba, Arshad, Fareeha, Hassan, Israr U., Pedram, Mona Zamani, Ahmed, Waqar, Faruck, Hakkim L., Aljabali, Alaa A. A., Mishra, Vijay, Serrano‐Aroca, Ángel, Goyal, Rohit, Negi, Poonam, Birkett, Martin, Nasef, Mohamed M., Charbe, Nitin B., Bakshi, Hamid A. and Tambuwala, Murtaza M. (2021) Fourth Generation Glucose Sensors Composed of Copper Nanostructures for Diabetes Management: A Critical Review. Bioengineering & Translational Medicine. ISSN 2380-6761 (In Press)

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More than five decades have been invested in understanding glucose biosensors. Yet, this immensely versatile field has continued to gain attention from the scientific world to better understand and diagnose diabetes. However, such extensive work done to improve glucose sensing devices has still not yielded desirable results. Drawbacks like the necessity of the invasive finger pricking step and the lack of optimization of diagnostic interventions still need to be considered to improve the testing process of diabetic patients. To upgrade the glucose-sensing devices and reduce the number of intermediary steps during glucose measurement, fourth-generation glucose sensors (FGGS) have been introduced. These sensors, made using robust electrocatalytic copper nanostructures, improve diagnostic efficiency and cost-effectiveness. This review aims to present the essential scientific progress in copper nanostructure-based FGGS in the past ten years (2010 – present). After a short introduction, we presented the working principles of these sensors. We then highlighted the importance of copper nanostructures as advanced electrode materials to develop reliable real-time FGGS. Finally, we cover the advantages, shortcomings, and prospects for developing highly sensitive, stable, and specific FGGS.

Item Type: Article
Additional Information: Funding information: Gowhar A. Naikoo, Tasbiha Awan, Hiba Salim, Israr Ul Hassan acknowledge the support received from The Research Council (TRC), Oman under the grant (Ref: BFP/RGP/HSS/18/122) to accomplish this work successfully.
Subjects: B800 Medical Technology
Department: Faculties > Engineering and Environment > Mechanical and Construction Engineering
Depositing User: Elena Carlaw
Date Deposited: 23 Aug 2021 15:23
Last Modified: 23 Aug 2021 15:30

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