Metabolic syndrome alters relationships between cardiometabolic variables, cognition and white matter hyperintensity load

Alkan, E., Taporoski, T. P., Sterr, A., von Schantz, Malcolm, Vallada, H., Krieger, J. E., Pereira, A. C., Alvim, R., Horimoto, A. R. V. R., Pompéia, S., Negrão, A. B. and Evans, S. L. H. (2019) Metabolic syndrome alters relationships between cardiometabolic variables, cognition and white matter hyperintensity load. Scientific Reports, 9 (1). p. 4356. ISSN 2045-2322

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Official URL: https://doi.org/10.1038/s41598-019-40630-6

Abstract

Cardiometabolic risk factors influence white matter hyperintensity (WMH) development: in metabolic syndrome (MetS), higher WMH load is often reported but the relationships between specific cardiometabolic variables, WMH load and cognitive performance are uncertain. We investigated these in a Brazilian sample (aged 50–85) with (N = 61) and without (N = 103) MetS. Stepwise regression models identified effects of cardiometabolic and demographic variables on WMH load (from FLAIR MRI) and verbal recall performance. WMH volume was greater in MetS, but verbal recall performance was not impaired. Age showed the strongest relationship with WMH load. Across all participants, systolic blood pressure (SBP) and fasting blood glucose were also contributors, and WMH volume was negatively associated with verbal recall performance. In non-MetS, higher HbA1c, SBP, and number of MetS components were linked to poorer recall performance while higher triglyceride levels appeared to be protective. In MetS only, these relationships were absent but education exerted a strongly protective effect on recall performance. Thus, results support MetS as a construct: the clustering of cardiometabolic variables in MetS alters their individual relationships with cognition; instead, MetS is characterised by a greater reliance on cognitive reserve mechanisms. In non-MetS, strategies to control HbA1c and SBP should be prioritised as these have the largest impact on cognition.

Item Type: Article
Additional Information: Funding Information: We are grateful to the population of Baependi for their participation in the Baependi Heart Study. This study was supported by grants from Fundação de Amparo a Pesquisa do Estado de São Paulo (FAPESP, 2013/17368-0, to A.P.), a PSDE grant from CAPES (Process 88881.133487/2016-01) to TPT, awards from CNPq to HV (400791/2015-5), the Global Innovation Initiative (jointly funded by the British Council and the UK Department of Business and Skills) to MvS, and Hospital Samaritano (Grant 25000.180.664/2011-35) through the Ministry of Health to Support Program Institutional Development of the Unified Health System (SUS-PROADI) to JEK. EA is supported by a studentship from the Government of Turkey.
Subjects: B100 Anatomy, Physiology and Pathology
B900 Others in Subjects allied to Medicine
C800 Psychology
Department: Faculties > Health and Life Sciences > Psychology
Depositing User: Rachel Branson
Date Deposited: 26 Aug 2021 13:32
Last Modified: 26 Aug 2021 13:45
URI: http://nrl.northumbria.ac.uk/id/eprint/47012

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