Nosocomial or not? A combined epidemiological and genomic investigation to understand hospital-acquired COVID-19 infection on an elderly care ward

Wenlock, R.D., Tausan, M., Mann, R., Garr, W., Preston, R., Arnold, A., Hoban, J., Webb, L., Quick, C., Beckett, A., Loveson, K., Glaysher, S., Elliott, S., Malone, C., Cogger, B., Easton, L., The COVID-19 Genomics UK (COG-UK) Consortium, , Allan, John, Bashton, Matthew, Loh, Joshua, Nelson, Andrew, Smith, Darren L., Yew, Wen Chyin, Young, Gregory R., Robson, S.C., Hassan-Ibrahim, M.O. and Sargent, C. (2021) Nosocomial or not? A combined epidemiological and genomic investigation to understand hospital-acquired COVID-19 infection on an elderly care ward. Infection Prevention in Practice. p. 100165. ISSN 2590-0889 (In Press)

[img]
Preview
Text (Proof)
1-s2.0-S2590088921000548-main.pdf - Accepted Version
Available under License Creative Commons Attribution Non-commercial No Derivatives 4.0.

Download (831kB) | Preview
Official URL: https://doi.org/10.1016/j.infpip.2021.100165

Abstract

Background:
COVID-19 has the potential to cause outbreaks in hospitals. Given the comorbid and elderly cohort of patients hospitalized, hospital-acquired COVID-19 infection is often fatal. Pathogen genome sequencing is becoming increasingly important in infection prevention and control (IPC).

Aim:
To inform the understanding of in-hospital SARS-CoV-2 transmission in order to improve IPC practices and to inform the future development of virological testing for IPC.

Methods:
Patients detected COVID-19 positive by polymerase chain reaction on Ward A in April and May 2020 were included with contact tracing to identify other potential cases. Genome sequencing was undertaken for a subgroup of cases. Epidemiological, genomic, and cluster analyses were performed to describe the epidemiology and to identify factors contributing to the outbreak.

Findings:
Fourteen cases were identified on Ward A. Contact tracing identified 16 further patient cases; in addition, eight healthcare workers (HCWs) were identified as being COVID-19 positive through a round of asymptomatic testing. Genome sequencing of 16 of these cases identified viral genomes differing by two single nucleotide polymorphisms or fewer, with further cluster analysis identifying two groups of infection (a five-person group and a six-person group).

Conclusion:
Despite the temporal relationship of cases, genome sequencing identified that not all cases shared transmission events. However, 11 samples were found to be closely related and these likely represented in-hospital transmission. This included three HCWs, thereby confirming transmission between patients and HCWs.

Item Type: Article
Uncontrolled Keywords: COVID-19, Hospital-acquired infection, Outbreak, Genome sequencing
Subjects: A300 Clinical Medicine
C400 Genetics
C700 Molecular Biology, Biophysics and Biochemistry
Department: Faculties > Health and Life Sciences > Applied Sciences
Depositing User: John Coen
Date Deposited: 09 Sep 2021 10:11
Last Modified: 09 Sep 2021 12:45
URI: http://nrl.northumbria.ac.uk/id/eprint/47116

Actions (login required)

View Item View Item

Downloads

Downloads per month over past year

View more statistics