Identification of the phase composition of solid microparticles in the nasal mucosa of patients with chronic hypertrophic rhinitis using Raman microspectroscopy

Čabanová, Kristina, Motyka, Oldřich, Bielniková, Hana, Čábalová, Lenka, Handlos, Petr, Zabiegaj, Dominika, Zeleník, Karol, Dvořáčková, Jana, Komínek, Pavel, Heviánková, Silvie, Havlíček, Miroslav and Kukutschová, Jana (2021) Identification of the phase composition of solid microparticles in the nasal mucosa of patients with chronic hypertrophic rhinitis using Raman microspectroscopy. Scientific Reports, 11 (1). p. 18989. ISSN 2045-2322

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Solid particles, predominantly in micron and submicron sizes, have repeatedly been observed as a threat to a human health unique compared to the other textures of the same materials. In this work, the hypothesis the solid metal-based particles play a role in the pathogenesis of chronic hypertrophic rhinitis was investigated in patients who had not responded positively to medication. In the group of 40 randomly selected patients indicated for surgical mucotomy, the presence of solid micro- and submicron particles present in their nasal mucosa was assessed. For comparison, a set of 13 reference samples from patients without diagnosed chronic hypertrophic rhinitis was evaluated. The analysis was performed using Raman microspectroscopy. The advantage of this method is the direct identification of compounds. The main detected compounds in the mucosa samples of patients with chronic hypertrophic rhinitis were TiO2, carbon-based compounds, CaCO3, Ca(Fe, Mg, Mn)(CO3)2 MgCO3, Fe2O3, BaSO4, FeCO3 and compounds of Al and Si, all of which may pose a health risk to a living organism. In the reference samples, only TiO2 and amorphous carbon were found. In the control group mucosa, a significantly lower presence of most of the assessed compounds was found despite the longer time they had to accumulate them due to their higher mean age. Identification and characterisation of such chemicals compounds in a living organism could contribute to the overall picture of the health of the individual and lead to a better understanding of the possible causes not only in the chronic hypertrophic rhinitis, but also in other mucosal and idiopathic diseases.

Item Type: Article
Additional Information: Funding information: This study was funded by project No. CZ.02.1.01/0.0/0.0/17_049/0008441 “Innovative therapeutic methods of musculoskeletal system in accident surgery” within the Research and Development for Innovations Operational Programme financed by the European Union and by the project “Centre of environmental research: Waste management, circular economy and environmental security” No. SS02030008 and co-funded by the Technology agency of the Czech Republic within the Environment for Life programme and by project No. LTI19008 “National contact centre for non-exhaust traffic emissions” within the Programme INTER EXCELLENCE, subprogramme INTER INFORM financed by the state budget of the Czech Republic.
Uncontrolled Keywords: Environmental sciences, Materials chemistry, Respiratory tract diseases
Subjects: A300 Clinical Medicine
B800 Medical Technology
F200 Materials Science
F300 Physics
Department: Faculties > Engineering and Environment > Mechanical and Construction Engineering
Depositing User: John Coen
Date Deposited: 24 Sep 2021 08:15
Last Modified: 19 Oct 2021 13:23

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