Syntrophic propionate-oxidizing bacteria in methanogenic systems

Westerholm, Maria, Calusinska, Magdalena and Dolfing, Jan (2021) Syntrophic propionate-oxidizing bacteria in methanogenic systems. FEMS Microbiology Reviews. fuab057. ISSN 0168-6445 (In Press)

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Official URL: https://doi.org/10.1093/femsre/fuab057

Abstract

The mutual nutritional cooperation underpinning syntrophic propionate degradation provides a scant amount of energy for the microorganisms involved, so propionate degradation often acts as a bottleneck in methanogenic systems. Understanding the ecology, physiology, and metabolic capacities of syntrophic propionate-oxidizing bacteria is of interest in both engineered and natural ecosystems, as it offers prospects to guide further development of technologies for biogas production and biomass-derived chemicals, and is important in forecasting contributions by biogenic methane emissions to climate change. Syntrophic propionate-oxidizing bacteria are distributed across different phyla. They can exhibit broad metabolic capabilities in addition to syntrophy (e.g. fermentative, sulfidogenic, and acetogenic metabolism) and demonstrate variations in interplay with cooperating partners, indicating nuances in their syntrophic lifestyle. In this review, we discuss distinctions in gene repertoire and organization for the methylmalonyl-CoA pathway, hydrogenases and formate dehydrogenases, and emerging facets of (formate/hydrogen/direct) electron transfer mechanisms. We also use information from cultivations, thermodynamic calculations, and omic analyses as the basis for identifying environmental conditions governing propionate oxidation in various ecosystems. Overall, this review improves basic and applied understanding of syntrophic propionate-oxidizing bacteria and highlights knowledge gaps, hopefully encouraging future research and engineering on propionate metabolism in biotechnological processes.

Item Type: Article
Additional Information: Funding information: MW is supported by the HR2020 ERC - Grant European Research Council (grant number 948138) and the Swedish Research Council for Environment, Agricultural Sciences and Spatial Planning (Formas) (grant number 2012-808). MC is supported by FNR CORE 2017 project CLOMICS (Grant number: C17/SR/11687962). JD gratefully acknowledges start-up funding from Northumbria University.
Uncontrolled Keywords: propionic acid, syntrophy, methanogenesis, methylmalonyl-CoA pathway, interspecies electron transfer, anaerobic digestion
Subjects: C500 Microbiology
H800 Chemical, Process and Energy Engineering
Department: Faculties > Engineering and Environment > Mechanical and Construction Engineering
Depositing User: John Coen
Date Deposited: 20 Dec 2021 15:25
Last Modified: 11 Jan 2022 13:30
URI: http://nrl.northumbria.ac.uk/id/eprint/48023

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