Activity Interference in Patient’s with Sjögren’s Syndrome: A Cross-Sectional Study of 149 Patients in the UK

Schoon, Hannah, Slack, Emma, Pearce, Mark, Ng, Wan-Fai and Hackett, Katie (2022) Activity Interference in Patient’s with Sjögren’s Syndrome: A Cross-Sectional Study of 149 Patients in the UK. Rheumatology. keac053. ISSN 1462-0324 (In Press)

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To investigate which five activity interference categories out of pain, fatigue, mood, dryness and brain fog/mental fatigue scored highest in patients with primary Sjögren's syndrome (pSS) and to investigate the association between activity interference and mood and physical functioning in these patients. The Comprehensive Pain Evaluation Questionnaire (CPEQ) assessed activity interference (actions performed in daily life that are hindered) in 149 UK pSS patients. This was modified to include four additional symptoms (fatigue, mood, dryness and brainfog/mental fatigue). Functional impairment was measured using the Hospital Anxiety and Depression Scale (HADS) and the Improved Health Assessment Questionnaire (Improved HAQ). Univariable linear regression models were estimated to investigate the association between CPEQ results and the outcome scores obtained from the HADS and Improved HAQ. Multivariable linear regression models were estimated adjusting for patient age and length of disease. Fatigue had the biggest impact on seven activity domains: physical exercise (mean score of 3.49 out of 5 [s.d. 1.26]), performing household chores (mean 3.14 [s.d. 1.18]), gardening or shopping (mean 3.18 [s.d. 1.20]), socializing with others (mean 2.62 [s.d. 1.24]), recreation/hobbies (mean 2.88 [s.d. 1.20]), sexual relations (mean 3.00 [s.d. 1.52]), and mental efficacy (mean 2.69 [s.d. 1.17]). Regression analysis showed a positive correlation in which every point increase in an activity interference category saw the overall mood and physical functioning scores increase. Fatigue has the largest impact on pSS patients' daily activities in this cohort. Length of disease reduced the impact of activity interference on patients' overall health score.

Item Type: Article
Additional Information: Funding information: This work was funded by Arthritis Research UK (Grant 20169 and Grant 22026)
Uncontrolled Keywords: Sjögren’s Syndrome, activity interference, autoimmunity
Subjects: B100 Anatomy, Physiology and Pathology
B900 Others in Subjects allied to Medicine
Department: Faculties > Health and Life Sciences > Social Work, Education and Community Wellbeing
Depositing User: Elena Carlaw
Date Deposited: 26 Jan 2022 09:33
Last Modified: 07 Apr 2022 09:45

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