A systems-approach to NAD+ restoration

Conlon, Nichola and Ford, Dianne (2022) A systems-approach to NAD+ restoration. Biochemical pharmacology, 198. p. 114946. ISSN 0006-2952

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Official URL: https://doi.org/10.1016/j.bcp.2022.114946


A decline in NAD+ is a feature of ageing and may play a causal role in the process. NAD+ plays a pivotal role in myriad processes important in cellular metabolism and is a cosubstrate for enzymes that play key roles in pathways that modify ageing. Thus, interventions that increase NAD+ may slow aspects of the ageing trajectory and there is great interest in pharmacological NAD+ restoration. Dietary supplementation with NAD+ precursors, particularly nicotinamide riboside, has increased NAD+ levels in several human intervention studies and arguably been the most robust approach to date. However, consistency and reliability of such approaches to increase NAD+, and also impact on markers of efficacy to slow or reverse features of ageing, has been inconsistent. We argue that a major element of this variability may arise from the use of single-target approaches that do not consider the underlying biological complexity leading to NAD+ decline. Thus, a systems approach – targeting multiple key nodes in the NAD+ interactome – is likely to be more efficacious and reliable.

Item Type: Article
Uncontrolled Keywords: NAD+, NAMPT, CD38, NNMT, NR, NMM
Subjects: C700 Molecular Biology, Biophysics and Biochemistry
Department: Faculties > Health and Life Sciences > Applied Sciences
Depositing User: John Coen
Date Deposited: 21 Feb 2022 12:58
Last Modified: 21 Feb 2022 13:00
URI: http://nrl.northumbria.ac.uk/id/eprint/48503

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