Effects of cycling intensity on acute signaling adaptations to 8-weeks concurrent training in trained cyclists

Jones, Thomas, Eddens, L, Kupusarevic, J, Camargo Madeira Simoes, Davina, Furber, MJW, Van Someren, KA and Howatson, Glyn (2022) Effects of cycling intensity on acute signaling adaptations to 8-weeks concurrent training in trained cyclists. Frontiers in Physiology, 13. p. 852595. ISSN 1664-042X

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Official URL: https://doi.org/10.3389/fphys.2022.852595

Abstract

This study examined whether the intensity of endurance stimuli modifies the adaptation in strength and endurance following concurrent training and whether the acute molecular response to concurrent exercise is affected by training status.Using a parallel group design, trained cyclists were randomized to either resistance exercise followed by moderate intensity continuous training (RES+MICT, n=6), or resistance exercise followed by work matched high intensity interval training (RES+HIIT, n=7), across an 8 wk training programme. A single RES+MICT or RES+HIIT exercise stimulus was completed 1 wk before and within 5 d of completing the training programme, to assess phosphorylation of protein kinases of the mTOR and AMPK signaling pathways.There were no main effects of time or group on the phosphorylation of protein kinases in response to concurrent exercise stimulus pre- and post-training intervention (p>0.05). Main effects of time were observed for all maximal strength exercises; back-squat, split-squat, and calf-raise (p<0.001), with all improving post intervention. A time x group interaction was present for \.VO2peak, with the RES+MICT group displaying a preferential response to that of the RES+HIIT group (p=0.010). No time nor group effects were observed for 5 min time trial performance, power at 2 and 4 mmol·L-1 (p>0.05).Whilst preliminary data due to limited sample size the intensity of endurance activity had no effect on performance outcomes, following concurrent training. Further, the acute molecular response to a concurrent exercise stimulus was comparable before and after the training intervention, suggesting that training status had no effect on the molecular responses assessed.

Item Type: Article
Uncontrolled Keywords: interference effect, anabolic, combined exercise, strength, endurance
Subjects: C600 Sports Science
C700 Molecular Biology, Biophysics and Biochemistry
Department: Faculties > Health and Life Sciences > Applied Sciences
Faculties > Health and Life Sciences > Sport, Exercise and Rehabilitation
Depositing User: John Coen
Date Deposited: 03 Mar 2022 12:46
Last Modified: 04 Apr 2022 08:45
URI: http://nrl.northumbria.ac.uk/id/eprint/48602

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