Wheat amylase/trypsin inhibitors (ATIs): occurrence, function and health aspects

Geisslitz, Sabrina, Weegels, Peter, Shewry, Peter, Zevallos Herencia, Victor, Masci, Stefania, Sorrells, Mark, Gregorini, Armando, Colomba, Mariastella, Jonkers, Daisy, Huang, Xin, De Giorgio, Roberto, Caio, Giacomo P., D’Amico, Stefano, Larré, Colette and Brouns, Fred (2022) Wheat amylase/trypsin inhibitors (ATIs): occurrence, function and health aspects. European Journal of Nutrition. ISSN 1436-6207 (In Press)

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Official URL: https://doi.org/10.1007/s00394-022-02841-y

Abstract

Amylase/trypsin inhibitors (ATIs) are widely consumed in cereal-based foods and have been implicated in adverse reactions to wheat exposure, such as respiratory and food allergy, and intestinal responses associated with coeliac disease and non-coeliac wheat sensitivity. ATIs occur in multiple isoforms which differ in the amounts present in different types of wheat (including ancient and modern ones). Measuring ATIs and their isoforms is an analytical challenge as is their isolation for use in studies addressing their potential effects on the human body. ATI isoforms differ in their spectrum of bioactive effects in the human gastrointestinal (GI), which may include enzyme inhibition, inflammation and immune responses and of which much is not known. Similarly, although modifications during food processing (exposure to heat, moisture, salt, acid, fermentation) may affect their structure and activity as shown in vitro, it is important to relate these changes to effects that may present in the GI tract. Finally, much of our knowledge of their potential biological effects is based on studies in vitro and in animal models. Validation by human studies using processed foods as commonly consumed is warranted. We conclude that more detailed understanding of these factors may allow the effects of ATIs on human health to be better understood and when possible, to be ameliorated, for example by innovative food processing. We therefore review in short our current knowledge of these proteins, focusing on features which relate to their biological activity and identifying gaps in our knowledge and research priorities.

Item Type: Article
Additional Information: Funding information: Open Access funding enabled and organized by Projekt DEAL. Open access under a CC BY licence (Creative Commons Attribution 4.0 International license) and waiving of related APC costs was possible by participation of Maastricht University and Karlsruhe Institute of Technology.
Uncontrolled Keywords: Amylase/trypsin inhibitors, ATIs, Coeliac disease, Intestinal symptoms, Non-coeliac wheat sensitivity, Wheat allergy
Subjects: B400 Nutrition
C500 Microbiology
C700 Molecular Biology, Biophysics and Biochemistry
Department: Faculties > Health and Life Sciences > Applied Sciences
Depositing User: Rachel Branson
Date Deposited: 18 Mar 2022 10:07
Last Modified: 18 Mar 2022 10:15
URI: http://nrl.northumbria.ac.uk/id/eprint/48696

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