Synthesis and evaluation of novel chromogenic peptidase substrates based on 9-(4′-aminophenyl)-10-methylacridinium salts as diagnostic tools in clinical bacteriology

Anderson, Rosaleen, Groundwater, Paul, Huang, Yongxue, James, Arthur, Orenga, Sylvain, Rigby, Annette, Roger-Dalbert, Céline and Perry, John (2008) Synthesis and evaluation of novel chromogenic peptidase substrates based on 9-(4′-aminophenyl)-10-methylacridinium salts as diagnostic tools in clinical bacteriology. Bioorganic & Medicinal Chemistry Letters, 18 (2). pp. 832-835. ISSN 0960-894X

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Abstract

The synthesis and initial evaluation of novel chromogenic substrates with potential in the detection and differentiation of cultured bacterial colonies are described. The substrates were readily hydrolysed by specific aminopeptidase activity to release the chromogen, 9-(4′-aminophenyl)-10-methylacridinium salt, which provided a clear visual indication of the presence of the corresponding bacteria.

Item Type:	Article
Uncontrolled Keywords:	microorganism detection, microorganism differentiation, clinical bacteriology, diagnostic reagent, chromogenic peptidase substrate, 9-(4′-Aminophenyl)-10-methylacridinium salt, alanine aminopeptidase, β-Alanine aminopeptidase, cystic fibrosis
Subjects:	C100 Biology C500 Microbiology
Department:	Faculties > Health and Life Sciences > Applied Sciences
Depositing User:	Ellen Cole
Date Deposited:	25 Jan 2012 12:03
Last Modified:	12 Oct 2019 17:31
URI:	http://nrl.northumbria.ac.uk/id/eprint/4933

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