Longitudinal Changes in Physical Activity Levels and Cardiovascular Risk Parameters in Patients with Symptomatic Peripheral Artery Disease

Monteiro, Francielly, Correia, Marilia de Almeida, Farah, Breno Quintella, Christofaro, Diego Giuliano Destro, Oliveira, Paulo Mesquita Longano de, Ritti-Dias, Raphael Mendes and Cucato, Gabriel (2022) Longitudinal Changes in Physical Activity Levels and Cardiovascular Risk Parameters in Patients with Symptomatic Peripheral Artery Disease. Arquivos Brasileiros de Cardiologia, 119 (1). pp. 59-66. ISSN 0066-782X

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Official URL: https://doi.org/10.36660/abc.20210386


Previous cross-sectional studies have demonstrated that physical activity is associated with lower cardiovascular risk in patients with peripheral artery disease (PAD). However, it is not possible to establish causality, and longitudinal design studies are required.

To analyze the changes in cardiovascular risk parameters and physical activity levels after a 2-year follow-up in patients with symptomatic PAD.Methods:This study started in 2015. In the first phase, 268 patients were included. In the second phase, after 2 years (median = 26 months), 72 patients were re-evaluated. Cardiovascular risk parameters, such as blood pressure, cardiac autonomic modulation, and arterial stiffness, and physical activity levels were measured at baseline and after 2 years of follow-up. Association among delta changes (values from follow-up – baseline) in physical activity and cardiovascular parameters were analyzed by multiple linear regression. The significance level was set at p < 0.05.

Patients reduced their total physical activity levels compared to baseline (baseline = 2257.6 ± 774.5 versus follow-up = 2041 ± 676.2 min/week, p = 0.001). After follow-up, ankle-brachial index (0.62 ± 0.20 versus 0.54 ± 0.20, p = 0.003), and standard deviation of all RR intervals (43.4 ± 27.0 versus 25.1 ± 13.4 ms, p < 0.001) were lower, whereas carotid-femoral pulse wave velocity was higher (9.0 ± 3.0 versus 10.7 ± 3.4 m/s, p = 0.002) compared to baseline values. We did not observe any association among delta values of physical activity levels and cardiovascular risk parameters.

Patients with PAD had reduced physical activity levels and impaired cardiovascular risk parameters during 2-year follow-up.

Item Type: Article
Additional Information: Funding information: This study was funded by CNPq - 4097072016-3.
Uncontrolled Keywords: Peripheral Arterial Disease. Cardiovascular System, Arterial Pressure, Exercise
Subjects: A300 Clinical Medicine
Department: Faculties > Health and Life Sciences > Sport, Exercise and Rehabilitation
Depositing User: John Coen
Date Deposited: 17 Aug 2022 13:50
Last Modified: 17 Aug 2022 14:00
URI: http://nrl.northumbria.ac.uk/id/eprint/49887

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