Impact of the quantity and flavonoid content of fruits and vegetables on markers of intake in adults with an increased risk of cardiovascular disease: the FLAVURS trial

Chong, Mary Foong-Fong, George, Trevor, Alimbetov, Dauren, Jin, Yannan, Weech, Michelle, MacReady, Anna, Spencer, Jeremy, Kennedy, Orla, Minihane, Anne-Marie, Gordon, Michael and Lovegrove, Julie (2013) Impact of the quantity and flavonoid content of fruits and vegetables on markers of intake in adults with an increased risk of cardiovascular disease: the FLAVURS trial. European Journal of Nutrition, 52 (1). pp. 361-378. ISSN 1436-6207

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Abstract

Purpose
Limited robust randomised controlled trials investigating fruit and vegetable (F&V) intake in people at risk of cardiovascular disease (CVD) exist. We aimed to design and validate a dietary strategy of increasing flavonoid-rich versus flavonoid-poor F&V consumption on nutrient biomarker profile.

Methods
A parallel, randomised, controlled, dose–response dietary intervention study. Participants with a CVD relative risk of 1.5 assessed by risk scores were randomly assigned to one of the 3 groups: habitual (control,CT), high-flavonoid (HF) or low-flavonoid (LF) diets.While the CT group (n = 57) consumed their habitual diet throughout, the HF (n = 58) and LF (n = 59) groups sequentially increased their daily F&V intake by an additional 2, 4 and 6 portions for 6-week periods during the 18-week study.

Results
Compliance to target numbers and types of F&V was broadly met and verified by dietary records, and plasma and urinary biomarkers. Mean (±SEM) number of F&V portions/day consumed by the HF and LF groups at baseline(3.8 ± 0.3 and 3.4 ± 0.3), 6 weeks (6.3 ± 0.4 and 5.8 ±0.3), 12 weeks (7.0 ± 0.3 and 6.8 ± 0.3) and 18 weeks(7.6 ± 0.4 and 8.1 ± 0.4), respectively, was similar at baseline yet higher than the CT group (3.9 ± 0.3, 4.3 ± 0.3,4.6 ± 0.4, 4.5 ± 0.3) (P = 0.015). There was a dosedependent increase in dietary and urinary flavonoids in theHF group, with no change in other groups (P = 0.0001).Significantly higher dietary intakes of folate (P = 0.035),non-starch polysaccharides (P = 0.001), vitamin C (P =0.0001) and carotenoids (P = 0.0001) were observed in both intervention groups compared with CT, which were broadly supported by nutrient biomarker analysis.

Conclusions
The success of improving nutrient profile by active encouragement of F&V intake in an intervention study implies the need for a more hands-on public health approach.

Item Type:	Article
Uncontrolled Keywords:	fruits, vegetables, bio-markers, dose response
Subjects:	D600 Food and Beverage studies
Department:	Faculties > Health and Life Sciences > Applied Sciences
Depositing User:	Linda Barlow
Date Deposited:	01 May 2012 16:31
Last Modified:	12 Oct 2019 18:28
URI:	http://nrl.northumbria.ac.uk/id/eprint/6689

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