Fiedler, Hans-Peter, Bruntner, Christina, Riedlinger, Julia, Bull, Alan, Knutsen, Gjert, Goodfellow, Michael, Jones, Amanda, Maldonado, Luis, Pathom-Aree, Wasu, Beil, Winfried, Schneider, Kathrin, Keller, Simone and Süssmuth, Roderich (2008) Proximicins A, B and C, novel aminofuran antibiotic and anticancer compounds isolated from marine strains of the actinomycete verrucosispora. Journal of Antibiotics, 61. pp. 158-163. ISSN 0021-8820
Full text not available from this repository. (Request a copy)Abstract
A family of three novel aminofuran antibiotics named as proximicins was isolated from the marine Verrucosispora strain MG-37. Proximicin A was detected in parallel in the marine abyssomicin producer "Verrucosispora maris" AB-18-032. The characteristic structural element of proximicins is 4-amino-furan-2-carboxylic acid, a hitherto unknown -amino acid. Proximicins show a weak antibacterial activity but a strong cytostatic effect to various human tumor cell lines.
| Item Type: | Article |
|---|---|
| Subjects: | C100 Biology C700 Molecular Biology, Biophysics and Biochemistry |
| Department: | Faculties > Health and Life Sciences > Applied Sciences |
| Depositing User: | EPrint Services |
| Date Deposited: | 01 Jun 2009 14:18 |
| Last Modified: | 31 Jul 2021 08:38 |
| URI: | http://nrl.northumbria.ac.uk/id/eprint/95 |
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