Iron-catalyzed cross-coupling between 1-Bromoalkynes and Grignard-derived organocuprate reagents

Castagnolo, Daniele and Botta, Maurizio (2010) Iron-catalyzed cross-coupling between 1-Bromoalkynes and Grignard-derived organocuprate reagents. European Journal of Organic Chemistry, 2010 (17). pp. 3224-3228. ISSN 1434-193X

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Abstract

An efficient iron-catalyzed cross-coupling reaction between alkynyl bromides and Grignard-derived organocuprates has been developed. A series of alkynylarenes were successfully synthesised by starting from different 1-bromoalkynes and Grignard reagents. The methodology was successfully used for the two-step stereoselective synthesis of combretastatins and represents a valid alternative to the classical syntheses of alkynylarenes

Item Type:	Article
Uncontrolled Keywords:	alkynes, Iron, Grignard reagents, homogeneous catalysis
Subjects:	F100 Chemistry
Department:	Faculties > Health and Life Sciences > Applied Sciences
Depositing User:	Linda Barlow
Date Deposited:	09 Jan 2013 09:43
Last Modified:	12 Oct 2019 18:26
URI:	http://nrl.northumbria.ac.uk/id/eprint/10978

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