Castagnolo, Daniele, Raffi, Francesco, Giorgi, Gianluca and Botta, Maurizio (2009) Macrocyclization of Di-Boc-guanidino-alkylamines Related to Guazatine Components: Discovery and synthesis of innovative macrocyclic amidinoureas. European Journal of Organic Chemistry, 2009 (3). pp. 334-337. ISSN 1434-193X
Full text not available from this repository. (Request a copy)Abstract
The synthesis of new and innovative macrocyclic amidinoureas from linear di-Boc-guanidino-alkylamines related to guazatine was accomplished. The macrocyclization reaction proceeds under mild conditions affording 11- to 16-membered rings with a new and previously undescribed structure in good yields. Enantiomerically pure macrocyclic amidinoureas were also synthesised. The strict correlation between macrocyclic amidinoureas and the natural productguazatine makes them very actractive also from a biological point of view.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | macrocyclization,amidino¬urea,aminoguanidine |
| Subjects: | F100 Chemistry |
| Department: | Faculties > Health and Life Sciences > Applied Sciences |
| Depositing User: | Linda Barlow |
| Date Deposited: | 09 Jan 2013 10:42 |
| Last Modified: | 12 Oct 2019 18:25 |
| URI: | http://nrl.northumbria.ac.uk/id/eprint/10979 |
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