Day, Kathryn, Ali, Shamshad, Ali Mirza, Irfin, Sidjabat, Hanna, Silvey, Anna, Lanyon, Clare, Cummings, Stephen, Abbasi, Shahid, Raza, Muhammad, Paterson, David and Perry, John (2013) Prevalence and molecular characterization of Enterobacteriaceae producing NDM-1 carbapenemase at a military hospital in Pakistan and evaluation of two chromogenic media. Diagnostic Microbiology and Infectious Disease, 75 (2). pp. 187-191. ISSN 0732-8893
Full text not available from this repository. (Request a copy)Abstract
The aim of this study was to assess the frequency and genotypic diversity of carbapenemase-producing
Enterobacteriaceae (CPE) in stool samples from patients attending a military hospital in Pakistan. Further aims included the identification of factors that might predispose to faecal carriage and evaluation of 2 chromogenic culture media: Brilliance CRE and chromID CARBA. Of 175 patients, 32 (18.3%) had faecal carriage of CPE and all produced NDM-1 carbapenemase. All of these 32 patients were detected using chromID CARBA compared with 20 patients (62.5%) detected using Brilliance CRE (P = 0.0015). Duration of hospitalization and treatment with coamoxyclav were statistically associated with a higher likelihood of carriage of CPE (P ≤ 0.05). Themajority of NDM-1–producing Enterobacteriaceae co-produced CTX-M-1 group extended spectrum β-lactamase, and one third produced armA-type methylase. NDM-1 carbapenemase was most commonly found amongst commensal types of Escherichia coli, especially phylogenetic group B1.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | carbapenemase, β-Lactamase, enterobacteriaceae, antimicrobial resistance |
| Subjects: | A100 Pre-clinical Medicine C500 Microbiology |
| Department: | Faculties > Health and Life Sciences > Applied Sciences |
| Related URLs: | |
| Depositing User: | Stephen Cummings |
| Date Deposited: | 26 Mar 2013 16:35 |
| Last Modified: | 12 Oct 2019 18:28 |
| URI: | http://nrl.northumbria.ac.uk/id/eprint/11626 |
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